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Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations.
ACR Open Rheumatol. 2022 Jun; 4(6):534-539.AO

Abstract

OBJECTIVE

The effects of coffee consumption on serum uric acid (SUA) levels and gout risk are controversial. There have hitherto been no reports based on Mendelian randomization (MR) analysis of its effects that consider pleiotropy. Here, we evaluated the effects of coffee consumption across ancestry populations, taking pleiotropy into account.

METHODS

We performed the first MR analyses for coffee consumption on SUA levels and gout, considering pleiotropy. We used the following summary statistics of genome-wide association studies from a Japanese population: habitual coffee consumption (152,634 subjects), gout (3053 cases and 4554 controls), and SUA levels (121,745 subjects). In addition to fixed-effect inverse variance weighted (IVW) meta-analysis, we performed a robust evaluation of heterogeneity and removed several instruments for reasons of possible pleiotropy. Previous European datasets were also reevaluated while heterogeneity was considered.

RESULTS

Habitual coffee consumption was significantly and inversely associated with gout (odds ratio [OR] = 0.29, 95% confidence interval [95% CI]: 0.16-0.51, P = 1.9 × 10-5) in random-effect IVW (Phet = 5.5 × 10-19). Excluding pleiotropic instruments, the protective effect on gout was confirmed in fixed-effect IVW analysis (OR = 0.75, 95% CI: 0.58-0.97, P = 0.026) without heterogeneity (Phet = 0.39). However, we observed no significance in the previous European datasets when heterogeneity was considered. Associations were not observed between coffee consumption and SUA levels in either ancestry in MR analyses that considered pleiotropy. Multivariable MR analysis showed that increased coffee consumption significantly reduced gout risk, even after adjusting for SUA levels (OR = 0.50, 95% CI: 0.31-0.81, P = 0.0046).

CONCLUSION

With pleiotropy taken into account, our MR analyses revealed that coffee consumption can causally reduce gout risk, and that it may reduce gout risk independently of SUA levels.

Links

Authors+Show Affiliations

Osaka University Graduate School of Medicine, Suita, Japan.

National Defense Medical College, Tokorozawa, Japan.

National Defense Medical College, Tokorozawa, Japan.

National Defense Medical College, Tokorozawa, Japan.

Nagoya University Graduate School of Medicine, Nagoya, Japan.

National Defense Medical College, Tokorozawa, Japan.

National Defense Medical College, Tokorozawa, Japan.

Osaka University Graduate School of Medicine and Osaka University, Suita, Japan, and RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

National Defense Medical College, Tokorozawa, Japan.

Japan Gout Genomics Consortium (Japan Gout)

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35348303

Citation

Shirai, Yuya, et al. "Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations." ACR Open Rheumatology, vol. 4, no. 6, 2022, pp. 534-539.

Shirai Y, Nakayama A, Kawamura Y, et al. Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations. ACR Open Rheumatol. 2022;4(6):534-539.

Shirai, Y., Nakayama, A., Kawamura, Y., Toyoda, Y., Nakatochi, M., Shimizu, S., Shinomiya, N., Okada, Y., & Matsuo, H. (2022). Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations. ACR Open Rheumatology, 4(6), 534-539. https://doi.org/10.1002/acr2.11425

Shirai Y, et al. Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations. ACR Open Rheumatol. 2022;4(6):534-539. PubMed PMID: 35348303.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Coffee Consumption Reduces Gout Risk Independently of Serum Uric Acid Levels: Mendelian Randomization Analyses Across Ancestry Populations. AU - Shirai,Yuya, AU - Nakayama,Akiyoshi, AU - Kawamura,Yusuke, AU - Toyoda,Yu, AU - Nakatochi,Masahiro, AU - Shimizu,Seiko, AU - Shinomiya,Nariyoshi, AU - Okada,Yukinori, AU - Matsuo,Hirotaka, AU - ,, Y1 - 2022/03/29/ PY - 2022/01/16/revised PY - 2021/08/16/received PY - 2022/01/26/accepted PY - 2022/3/30/pubmed PY - 2022/3/30/medline PY - 2022/3/29/entrez SP - 534 EP - 539 JF - ACR open rheumatology JO - ACR Open Rheumatol VL - 4 IS - 6 N2 - OBJECTIVE: The effects of coffee consumption on serum uric acid (SUA) levels and gout risk are controversial. There have hitherto been no reports based on Mendelian randomization (MR) analysis of its effects that consider pleiotropy. Here, we evaluated the effects of coffee consumption across ancestry populations, taking pleiotropy into account. METHODS: We performed the first MR analyses for coffee consumption on SUA levels and gout, considering pleiotropy. We used the following summary statistics of genome-wide association studies from a Japanese population: habitual coffee consumption (152,634 subjects), gout (3053 cases and 4554 controls), and SUA levels (121,745 subjects). In addition to fixed-effect inverse variance weighted (IVW) meta-analysis, we performed a robust evaluation of heterogeneity and removed several instruments for reasons of possible pleiotropy. Previous European datasets were also reevaluated while heterogeneity was considered. RESULTS: Habitual coffee consumption was significantly and inversely associated with gout (odds ratio [OR] = 0.29, 95% confidence interval [95% CI]: 0.16-0.51, P = 1.9 × 10-5) in random-effect IVW (Phet = 5.5 × 10-19). Excluding pleiotropic instruments, the protective effect on gout was confirmed in fixed-effect IVW analysis (OR = 0.75, 95% CI: 0.58-0.97, P = 0.026) without heterogeneity (Phet = 0.39). However, we observed no significance in the previous European datasets when heterogeneity was considered. Associations were not observed between coffee consumption and SUA levels in either ancestry in MR analyses that considered pleiotropy. Multivariable MR analysis showed that increased coffee consumption significantly reduced gout risk, even after adjusting for SUA levels (OR = 0.50, 95% CI: 0.31-0.81, P = 0.0046). CONCLUSION: With pleiotropy taken into account, our MR analyses revealed that coffee consumption can causally reduce gout risk, and that it may reduce gout risk independently of SUA levels. SN - 2578-5745 UR - https://www.unboundmedicine.com/medline/citation/35348303/Coffee_Consumption_Reduces_Gout_Risk_Independently_of_Serum_Uric_Acid_Levels:_Mendelian_Randomization_Analyses_Across_Ancestry_Populations_ DB - PRIME DP - Unbound Medicine ER -