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Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study.
Vaccine. 2022 Apr 26; 40(19):2733-2740.V

Abstract

We used an indirect cohort analysis in children under 5 years-old from 2002 to 2018 to examine vaccine effectiveness (VE) of the 7-valent pneumococcal conjugate vaccine (PCV) (3 + 1 doses in most regions) and the 13-valent PCV (2 + 1 doses in all regions) against invasive pneumococcal disease (IPD) caused by vaccine serotypes in children in Canada. Cases were identified from the Canadian Immunization Monitoring Program ACTive (IMPACT), a national active surveillance network of 12 tertiary care pediatric hospitals that represent about 90% of tertiary care hospital beds in Canada. There were 1477 children evaluated for PCV7 VE and 489 for PCV13 VE. PCV7 VE in children with vaccination up to date for their age was 96% (95% CI: 67-99%) after a single dose and 95% (95% CI: 92-97%) after ≥2 doses. The VE was 91% (95% CI: 85-94%) in children who had received doses but were not up to date for their age. PCV13 VE in children with vaccinations up to date for their age was 55% (95% CI: 28-72%) after ≥2 doses. The PCV13-vaccine serotypes causing breakthrough IPD in children up to date for their age with 2+ doses of PCV13 were 3 (13/27, 48.2%),19A (11/27, 40.7%), and 19F (3/27, 11.1%). When serotype 3 and 19A were excluded, the VE of PCV13 against the remaining vaccine serotypes was 89% (95% CI: 64-97%) in children with ≥2 doses. The lower VE of PCV13 may be due to lower effectiveness against serotypes 3 and 19A, which could be influenced by the change in dosing schedule from 4 to 3 total doses with the introduction of PCV13, combined with vaccine uptake of 80%. However, PCV13 still provides the benefit of protection against more serotypes than PCV7, and good VE against all serotypes except 3 and 19A.

Authors+Show Affiliations

Department of Pediatrics, University of Calgary, Calgary, AB, Canada.Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.Vaccine Evaluation Center, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.Canadian Centre for Vaccinology, Halifax, NS, Canada; Dalhousie University and the IWK Health Centre Dalhousie University, Halifax, NS, Canada.Department of Pediatrics, University of Calgary, Calgary, AB, Canada; Alberta Children's Hospital, Calgary Zone, Alberta Health Services, Calgary, AB, Canada. Electronic address: Jim.Kellner@albertahealthservices.ca.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35351324

Citation

Ricketson, Leah J., et al. "Vaccine Effectiveness of the 7-valent and 13-valent Pneumococcal Conjugate Vaccines in Canada: an IMPACT Study." Vaccine, vol. 40, no. 19, 2022, pp. 2733-2740.
Ricketson LJ, Bettinger JA, Sadarangani M, et al. Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study. Vaccine. 2022;40(19):2733-2740.
Ricketson, L. J., Bettinger, J. A., Sadarangani, M., Halperin, S. A., & Kellner, J. D. (2022). Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study. Vaccine, 40(19), 2733-2740. https://doi.org/10.1016/j.vaccine.2022.03.048
Ricketson LJ, et al. Vaccine Effectiveness of the 7-valent and 13-valent Pneumococcal Conjugate Vaccines in Canada: an IMPACT Study. Vaccine. 2022 Apr 26;40(19):2733-2740. PubMed PMID: 35351324.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccine effectiveness of the 7-valent and 13-valent pneumococcal conjugate vaccines in Canada: An IMPACT study. AU - Ricketson,Leah J, AU - Bettinger,Julie A, AU - Sadarangani,Manish, AU - Halperin,Scott A, AU - Kellner,James D, AU - ,, Y1 - 2022/03/26/ PY - 2021/11/09/received PY - 2022/03/18/revised PY - 2022/03/20/accepted PY - 2022/3/31/pubmed PY - 2022/4/19/medline PY - 2022/3/30/entrez KW - Invasive pneumococcal disease KW - Pneumococcal conjugate vaccines KW - Pneumococcus KW - Streptococcus pneumoniae KW - Vaccine effectiveness SP - 2733 EP - 2740 JF - Vaccine JO - Vaccine VL - 40 IS - 19 N2 - We used an indirect cohort analysis in children under 5 years-old from 2002 to 2018 to examine vaccine effectiveness (VE) of the 7-valent pneumococcal conjugate vaccine (PCV) (3 + 1 doses in most regions) and the 13-valent PCV (2 + 1 doses in all regions) against invasive pneumococcal disease (IPD) caused by vaccine serotypes in children in Canada. Cases were identified from the Canadian Immunization Monitoring Program ACTive (IMPACT), a national active surveillance network of 12 tertiary care pediatric hospitals that represent about 90% of tertiary care hospital beds in Canada. There were 1477 children evaluated for PCV7 VE and 489 for PCV13 VE. PCV7 VE in children with vaccination up to date for their age was 96% (95% CI: 67-99%) after a single dose and 95% (95% CI: 92-97%) after ≥2 doses. The VE was 91% (95% CI: 85-94%) in children who had received doses but were not up to date for their age. PCV13 VE in children with vaccinations up to date for their age was 55% (95% CI: 28-72%) after ≥2 doses. The PCV13-vaccine serotypes causing breakthrough IPD in children up to date for their age with 2+ doses of PCV13 were 3 (13/27, 48.2%),19A (11/27, 40.7%), and 19F (3/27, 11.1%). When serotype 3 and 19A were excluded, the VE of PCV13 against the remaining vaccine serotypes was 89% (95% CI: 64-97%) in children with ≥2 doses. The lower VE of PCV13 may be due to lower effectiveness against serotypes 3 and 19A, which could be influenced by the change in dosing schedule from 4 to 3 total doses with the introduction of PCV13, combined with vaccine uptake of 80%. However, PCV13 still provides the benefit of protection against more serotypes than PCV7, and good VE against all serotypes except 3 and 19A. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/35351324/Vaccine_effectiveness_of_the_7_valent_and_13_valent_pneumococcal_conjugate_vaccines_in_Canada:_An_IMPACT_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(22)00359-0 DB - PRIME DP - Unbound Medicine ER -