TY - JOUR T1 - Vulvovaginal atrophy management with a laser: the placebo effect or the conditioning Pavlov reflex. AU - Pérez-López,F R, AU - Varikasuvu,S R, Y1 - 2022/03/30/ PY - 2022/3/31/pubmed PY - 2022/7/12/medline PY - 2022/3/30/entrez KW - Carbon dioxide laser KW - dyspareunia KW - estrogen KW - female sexual function KW - genitourinary syndrome of menopause KW - meta-analysis KW - vulvovaginal atrophy SP - 323 EP - 326 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 25 IS - 4 N2 - Postmenopausal vulvovaginal pain and atrophy require appropriate and sensitive outcomes that correlate with the genital discomfort, symptoms and expected changes. In some studies, hormone and laser treatments do not detect benefits due to the fact that appropriate measuring tools were not used. While some studies have demonstrated placebo effects for both therapeutic approaches, others support that sham-intervention could be a therapeutic by creating a conditioning reflex. However, obtained results are directly related with the quality of outcomes: you get what you measure. It is imperative to follow the Core Outcomes in Menopause global initiative. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35352627/Vulvovaginal_atrophy_management_with_a_laser:_the_placebo_effect_or_the_conditioning_Pavlov_reflex. DB - PRIME DP - Unbound Medicine ER -