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Prevalence of sensitivity to sulfiting agents in asthmatic patients.
Am J Med 1986; 81(5):816-20AJ

Abstract

Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients had a positive response. Moreover, only one of five non-steroid-dependent patients had a response to double-blind challenge. On the basis of this challenge study, the best estimate of the prevalence of sulfite sensitivity in the asthmatic patients studied is 3.9 percent. This population, however, contained a larger number of steroid-dependent asthmatic patients than would be found in the general asthmatic population. It is concluded, therefore, that the prevalence of sulfite sensitivity in the asthmatic population as a whole would be less than 3.9 percent and that steroid-dependent asthmatic patients are most at risk.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3535492

Citation

Bush, R K., et al. "Prevalence of Sensitivity to Sulfiting Agents in Asthmatic Patients." The American Journal of Medicine, vol. 81, no. 5, 1986, pp. 816-20.
Bush RK, Taylor SL, Holden K, et al. Prevalence of sensitivity to sulfiting agents in asthmatic patients. Am J Med. 1986;81(5):816-20.
Bush, R. K., Taylor, S. L., Holden, K., Nordlee, J. A., & Busse, W. W. (1986). Prevalence of sensitivity to sulfiting agents in asthmatic patients. The American Journal of Medicine, 81(5), pp. 816-20.
Bush RK, et al. Prevalence of Sensitivity to Sulfiting Agents in Asthmatic Patients. Am J Med. 1986;81(5):816-20. PubMed PMID: 3535492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of sensitivity to sulfiting agents in asthmatic patients. AU - Bush,R K, AU - Taylor,S L, AU - Holden,K, AU - Nordlee,J A, AU - Busse,W W, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 816 EP - 20 JF - The American journal of medicine JO - Am. J. Med. VL - 81 IS - 5 N2 - Ingestion of sulfiting agents can induce wheezing in some asthmatic patients. However, neither the prevalence of sulfite sensitivity nor the clinical characteristics of the affected asthmatic population are known. In a prospective single-blind screening study, 120 non-steroid-dependent and 83 steroid-dependent asthmatic patients underwent challenge with oral capsules of potassium metabisulfite. Five non-steroid-dependent and 16 steroid-dependent asthmatic patients experienced a greater than 20 percent reduction in their one-second forced expiratory volume within 30 minutes following the oral challenge. Twelve of these sulfite reactors were rechallenged with metabisulfite capsules in a double-blind protocol. Under these conditions, only three of seven steroid-dependent patients had a positive response. Moreover, only one of five non-steroid-dependent patients had a response to double-blind challenge. On the basis of this challenge study, the best estimate of the prevalence of sulfite sensitivity in the asthmatic patients studied is 3.9 percent. This population, however, contained a larger number of steroid-dependent asthmatic patients than would be found in the general asthmatic population. It is concluded, therefore, that the prevalence of sulfite sensitivity in the asthmatic population as a whole would be less than 3.9 percent and that steroid-dependent asthmatic patients are most at risk. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/3535492/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9343(86)90351-7 DB - PRIME DP - Unbound Medicine ER -