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BNT162b2 and ChAdOx1 nCoV-19 vaccinations, incidence of SARS-CoV-2 infections and COVID-19 hospitalisations in Scotland in the Delta era.
J Glob Health. 2022; 12:05008.JG

Abstract

Background

The emergence of the B.1.617.2 Delta variant of concern was associated with increasing numbers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and COVID-19 hospital admissions. We aim to study national population level SARS-CoV-2 infections and COVID-19 associated hospitalisations by vaccination status to provide insight into the association of vaccination on temporal trends during the time in which the SARS-CoV-2 Delta variant became dominant in Scotland.

Methods

We used the Scotland-wide Early Pandemic Evaluation and Enhanced Surveillance (EAVE II) platform, covering the period when Delta was pervasive (May 01 to October 23, 2021). We performed a cohort analysis of every vaccine-eligible individual aged 20 or over from across Scotland. We determined the vaccination coverage, SARS-CoV-2 incidence rate and COVID-19 associated hospitalisations incidence rate. We then stratified those rates by age group, vaccination status (defined as "unvaccinated", "partially vaccinated" (1 dose), or "fully vaccinated" (2 doses)), vaccine type (BNT162b2 or ChAdOx1 nCoV-19), and coexisting conditions known to be associated with severe COVID-19 outcomes.

Results

During the follow-up of 4 183 022 individuals, there were 407 405 SARS-CoV-2 positive cases with 10 441 (2.6%) associated with a hospital admission. Those vaccinated with two doses (defined as fully vaccinated in the current study) of either vaccine had lower incidence rates of SARS-CoV-2 infections and much lower incidence rates of COVID-19 associated hospitalisations than those unvaccinated in the Delta era in Scotland. Younger age groups were substantially more likely to get infected. In contrast, older age groups were much more likely to be hospitalised. The incidence rates stratified by coexisting conditions were broadly comparable with the overall age group patterns.

Conclusions

This study suggests that national population level vaccination was associated with a reduction in SARS-CoV-2 infections and COVID-19 associated hospitalisation in Scotland throughout the Delta era.

Links

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Authors+Show Affiliations

Shah SA
Usher Institute, University of Edinburgh, Edinburgh, UK.
Robertson C
University of Strathclyde, Glasgow, Edinburgh, UK.
Rudan I
Usher Institute, University of Edinburgh, Edinburgh, UK.
Murray JL
Public Health Scotland, Glasgow, Edinburgh, UK.
McCowan C
School of Medicine, University of St Andrews, St Andrews, UK.
Grange Z
Public Health Scotland, Glasgow, Edinburgh, UK.
Buelo A
Public Health Scotland, Glasgow, Edinburgh, UK.
Sullivan C
Public Health Scotland, Glasgow, Edinburgh, UK.
Simpson CR
School of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington, New Zealand.
Ritchie LD
Academic Primary Care, University of Aberdeen, Aberdeen, UK.
Sheikh A
Usher Institute, University of Edinburgh, Edinburgh, UK.

MeSH

AdultAgedBNT162 VaccineCOVID-19ChAdOx1 nCoV-19HospitalizationHumansIncidenceSARS-CoV-2VaccinationViral VaccinesYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35356660

Citation

Shah, Syed Ahmar, et al. "BNT162b2 and ChAdOx1 nCoV-19 Vaccinations, Incidence of SARS-CoV-2 Infections and COVID-19 Hospitalisations in Scotland in the Delta Era." Journal of Global Health, vol. 12, 2022, p. 05008.
Shah SA, Robertson C, Rudan I, et al. BNT162b2 and ChAdOx1 nCoV-19 vaccinations, incidence of SARS-CoV-2 infections and COVID-19 hospitalisations in Scotland in the Delta era. J Glob Health. 2022;12:05008.
Shah, S. A., Robertson, C., Rudan, I., Murray, J. L., McCowan, C., Grange, Z., Buelo, A., Sullivan, C., Simpson, C. R., Ritchie, L. D., & Sheikh, A. (2022). BNT162b2 and ChAdOx1 nCoV-19 vaccinations, incidence of SARS-CoV-2 infections and COVID-19 hospitalisations in Scotland in the Delta era. Journal of Global Health, 12, 05008. https://doi.org/10.7189/jogh.12.05008
Shah SA, et al. BNT162b2 and ChAdOx1 nCoV-19 Vaccinations, Incidence of SARS-CoV-2 Infections and COVID-19 Hospitalisations in Scotland in the Delta Era. J Glob Health. 2022;12:05008. PubMed PMID: 35356660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BNT162b2 and ChAdOx1 nCoV-19 vaccinations, incidence of SARS-CoV-2 infections and COVID-19 hospitalisations in Scotland in the Delta era. AU - Shah,Syed Ahmar, AU - Robertson,Chris, AU - Rudan,Igor, AU - Murray,Josephine Lk, AU - McCowan,Colin, AU - Grange,Zoe, AU - Buelo,Audrey, AU - Sullivan,Christopher, AU - Simpson,Colin R, AU - Ritchie,Lewis D, AU - Sheikh,Aziz, Y1 - 2022/03/26/ PY - 2022/3/31/entrez PY - 2022/4/1/pubmed PY - 2022/4/2/medline SP - 05008 EP - 05008 JF - Journal of global health JO - J Glob Health VL - 12 N2 - Background: The emergence of the B.1.617.2 Delta variant of concern was associated with increasing numbers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and COVID-19 hospital admissions. We aim to study national population level SARS-CoV-2 infections and COVID-19 associated hospitalisations by vaccination status to provide insight into the association of vaccination on temporal trends during the time in which the SARS-CoV-2 Delta variant became dominant in Scotland. Methods: We used the Scotland-wide Early Pandemic Evaluation and Enhanced Surveillance (EAVE II) platform, covering the period when Delta was pervasive (May 01 to October 23, 2021). We performed a cohort analysis of every vaccine-eligible individual aged 20 or over from across Scotland. We determined the vaccination coverage, SARS-CoV-2 incidence rate and COVID-19 associated hospitalisations incidence rate. We then stratified those rates by age group, vaccination status (defined as "unvaccinated", "partially vaccinated" (1 dose), or "fully vaccinated" (2 doses)), vaccine type (BNT162b2 or ChAdOx1 nCoV-19), and coexisting conditions known to be associated with severe COVID-19 outcomes. Results: During the follow-up of 4 183 022 individuals, there were 407 405 SARS-CoV-2 positive cases with 10 441 (2.6%) associated with a hospital admission. Those vaccinated with two doses (defined as fully vaccinated in the current study) of either vaccine had lower incidence rates of SARS-CoV-2 infections and much lower incidence rates of COVID-19 associated hospitalisations than those unvaccinated in the Delta era in Scotland. Younger age groups were substantially more likely to get infected. In contrast, older age groups were much more likely to be hospitalised. The incidence rates stratified by coexisting conditions were broadly comparable with the overall age group patterns. Conclusions: This study suggests that national population level vaccination was associated with a reduction in SARS-CoV-2 infections and COVID-19 associated hospitalisation in Scotland throughout the Delta era. SN - 2047-2986 UR - https://www.unboundmedicine.com/medline/citation/35356660/BNT162b2_and_ChAdOx1_nCoV_19_vaccinations_incidence_of_SARS_CoV_2_infections_and_COVID_19_hospitalisations_in_Scotland_in_the_Delta_era_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↑15]

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