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Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination.
J Integr Neurosci. 2022 Mar 23; 21(2):70.JI

Abstract

BACKGROUND

The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studied. The objective of this study is to evaluate the skeletal alterations in the posterior cranial fossa (PCF) of adult CMI cases with and without group B BI.

METHODS

Fifty-four adult CMI without BI cases (CMI-only group) and 30 adult CMI with group B BI cases (CMI-BI group) were retrospectively studied. Fifty-six adult patients with unruptured intracranial aneurysms were included as the controls. Several linear and angular variables, and the bony volume of the PCF were analyzed based on thin-slice computed tomography data.

RESULTS

Morphological analysis revealed a significant difference in several variables from controls compared to CMI-only, and CMI-BI patients. The clivus and occipital bone, shortened and elevated in CMI-only patients, were further flattened in BI-associated CMI patients. Furthermore, although out of the scope for the diagnostic threshold of BI, the CMI-only cases also had a tendency to form BI. The association of BI modified several variables, without further reducing the bony PCF volume.

CONCLUSIONS

These findings indicate that the variables associated with group B BI tend to be a continuum of the same pathological abnormalities that originate from the same pathological alterations in CMI patients.

Authors+Show Affiliations

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, China.Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, China.Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, China.Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, China.Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, 400016 Yuzhong District, Chongqing, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35364658

Citation

Xia, Yongzhi, et al. "Morphometric and Volumetric Analysis of the Posterior Cranial Fossa in Adult Chiari Malformation Type I With and Without Group B Basilar Invagination." Journal of Integrative Neuroscience, vol. 21, no. 2, 2022, p. 70.
Xia Y, Xia H, Tang W, et al. Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination. J Integr Neurosci. 2022;21(2):70.
Xia, Y., Xia, H., Tang, W., Wang, S., & Yan, Y. (2022). Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination. Journal of Integrative Neuroscience, 21(2), 70. https://doi.org/10.31083/j.jin2102070
Xia Y, et al. Morphometric and Volumetric Analysis of the Posterior Cranial Fossa in Adult Chiari Malformation Type I With and Without Group B Basilar Invagination. J Integr Neurosci. 2022 Mar 23;21(2):70. PubMed PMID: 35364658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphometric and volumetric analysis of the posterior cranial fossa in adult Chiari malformation type I with and without group B basilar invagination. AU - Xia,Yongzhi, AU - Xia,Haijian, AU - Tang,Wei, AU - Wang,Shengxi, AU - Yan,Yi, PY - 2021/11/16/received PY - 2021/12/19/revised PY - 2021/12/31/accepted PY - 2022/4/1/entrez PY - 2022/4/2/pubmed PY - 2022/4/6/medline KW - Basilar invagination KW - Chiari malformation type I KW - Computer tomography KW - Foramen magnum decompression KW - Posterior cranial fossa SP - 70 EP - 70 JF - Journal of integrative neuroscience JO - J Integr Neurosci VL - 21 IS - 2 N2 - BACKGROUND: The frequent association of basilar invagination (BI) makes the understanding of the pathogenesis of Chiari malformation type I (CMI) difficult. The influence of group B type of BI (the BI without obvious atlantoaxial instability) on the skeletal morphology has not been thoroughly studied. The objective of this study is to evaluate the skeletal alterations in the posterior cranial fossa (PCF) of adult CMI cases with and without group B BI. METHODS: Fifty-four adult CMI without BI cases (CMI-only group) and 30 adult CMI with group B BI cases (CMI-BI group) were retrospectively studied. Fifty-six adult patients with unruptured intracranial aneurysms were included as the controls. Several linear and angular variables, and the bony volume of the PCF were analyzed based on thin-slice computed tomography data. RESULTS: Morphological analysis revealed a significant difference in several variables from controls compared to CMI-only, and CMI-BI patients. The clivus and occipital bone, shortened and elevated in CMI-only patients, were further flattened in BI-associated CMI patients. Furthermore, although out of the scope for the diagnostic threshold of BI, the CMI-only cases also had a tendency to form BI. The association of BI modified several variables, without further reducing the bony PCF volume. CONCLUSIONS: These findings indicate that the variables associated with group B BI tend to be a continuum of the same pathological abnormalities that originate from the same pathological alterations in CMI patients. SN - 0219-6352 UR - https://www.unboundmedicine.com/medline/citation/35364658/Morphometric_and_volumetric_analysis_of_the_posterior_cranial_fossa_in_adult_Chiari_malformation_type_I_with_and_without_group_B_basilar_invagination_ L2 - https://www.imrpress.com/journal/JIN/21/2/10.31083/j.jin2102070 DB - PRIME DP - Unbound Medicine ER -