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Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years?
Climacteric. 2022 Apr 06 [Online ahead of print]C

Abstract

OBJECTIVE

To investigate whether an earlier-onset climacteric phase is associated with autonomic imbalance at the age of 46 years.

METHODS

This cross-sectional birth cohort study included 2661 women aged 46 years. Participants were divided into climacteric (n = 359) and preclimacteric (n = 2302) groups based on menstrual history and follicle stimulating hormone values. The mean heart rate (HR), low-frequency (LF) power, high-frequency (HF) power and LF/HF ratio were analyzed from heart rate variability recordings. The variables were compared between the groups using multivariable linear regression models, including body mass index, smoking and physical activity. The effects of hormone therapy and hot flashes on autonomic function were evaluated in sub-analyses.

RESULTS

Climacteric women had a lower mean HR in seated (71.9 ± 10.5 vs. 72.6 ± 10.4 bpm, p = 0.015) and standing (81.2 ± 12.8 vs. 83.6 ± 12.1 bpm, p = 0.002) positions compared to preclimacteric women, and the differences remained significant after the adjustments. In the sub-analyses, more frequent hot flashes were associated with a lower LF power and LF/HF ratio in the sitting position.

CONCLUSIONS

The present study suggested an association between greater parasympathetic activation in women with more advanced climacteric status at the age of 46 years.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Oulu, Finland. Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Oulu, Finland. Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.Research Unit of Biomedicine, Medical Research Center, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland.Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland.Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Centre for Life Course Health Research, University of Oulu, Oulu, Finland.Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Oulu, Finland. Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. NordLab Oulu, Oulu University Hospital, Oulu, Finland. Department of Clinical Chemistry, University of Oulu, Oulu, Finland.Department of Obstetrics and Gynecology, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, OYS, Oulu, Finland. Medical Research Centre Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35383514

Citation

Salin, S, et al. "Does Climacteric Status Impact Regulation of the Autonomic Nervous System at the Age of 46 Years?" Climacteric : the Journal of the International Menopause Society, 2022, pp. 1-9.
Salin S, Savukoski S, Tulppo M, et al. Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years? Climacteric. 2022.
Salin, S., Savukoski, S., Tulppo, M., Pesonen, P., Auvinen, J., Suvanto, E., Puukka, K., & Niinimäki, M. (2022). Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years? Climacteric : the Journal of the International Menopause Society, 1-9. https://doi.org/10.1080/13697137.2022.2052842
Salin S, et al. Does Climacteric Status Impact Regulation of the Autonomic Nervous System at the Age of 46 Years. Climacteric. 2022 Apr 6;1-9. PubMed PMID: 35383514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does climacteric status impact regulation of the autonomic nervous system at the age of 46 years? AU - Salin,S, AU - Savukoski,S, AU - Tulppo,M, AU - Pesonen,P, AU - Auvinen,J, AU - Suvanto,E, AU - Puukka,K, AU - Niinimäki,M, Y1 - 2022/04/06/ PY - 2022/4/6/entrez PY - 2022/4/7/pubmed PY - 2022/4/7/medline KW - Autonomic function KW - early menopause KW - heart rate variability KW - hot flashes KW - menopause SP - 1 EP - 9 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric N2 - OBJECTIVE: To investigate whether an earlier-onset climacteric phase is associated with autonomic imbalance at the age of 46 years. METHODS: This cross-sectional birth cohort study included 2661 women aged 46 years. Participants were divided into climacteric (n = 359) and preclimacteric (n = 2302) groups based on menstrual history and follicle stimulating hormone values. The mean heart rate (HR), low-frequency (LF) power, high-frequency (HF) power and LF/HF ratio were analyzed from heart rate variability recordings. The variables were compared between the groups using multivariable linear regression models, including body mass index, smoking and physical activity. The effects of hormone therapy and hot flashes on autonomic function were evaluated in sub-analyses. RESULTS: Climacteric women had a lower mean HR in seated (71.9 ± 10.5 vs. 72.6 ± 10.4 bpm, p = 0.015) and standing (81.2 ± 12.8 vs. 83.6 ± 12.1 bpm, p = 0.002) positions compared to preclimacteric women, and the differences remained significant after the adjustments. In the sub-analyses, more frequent hot flashes were associated with a lower LF power and LF/HF ratio in the sitting position. CONCLUSIONS: The present study suggested an association between greater parasympathetic activation in women with more advanced climacteric status at the age of 46 years. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35383514/Does_climacteric_status_impact_regulation_of_the_autonomic_nervous_system_at_the_age_of_46_years DB - PRIME DP - Unbound Medicine ER -
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