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Cell-mediated immune responses to artificial food additives in chronic urticaria.
Clin Allergy. 1986 Nov; 16(6):527-33.CA

Abstract

In some cases of chronic urticaria it is suspected that food additives such as tartrazine and sodium benzoate or salicylates may play a role in the pathogenesis of the condition. Since, at times, chronic urticaria may appear histologically similar to a mild cell-mediated immune response, the release of the T cell-derived lymphokine leucocyte inhibitory factor (LIF), in response to incubation with these additives and with acetylsalicylic acid (ASA), was measured in vitro using cells from normal controls, from patients with chronic urticaria with or without clinically associated additive sensitivity and from patients with asthma with or without associated ASA sensitivity. It was found that significant production of LIF occurred in response to tartrazine and sodium benzoate in those individuals with chronic additive induced urticaria. In addition, tartrazine caused LIF release from mononuclear cells of ASA-sensitive asthmatics. These results may indicate a possible role for additive-induced cell-mediated immune responses in the pathogenesis of some cases of chronic urticaria and suggest a potential diagnostic test for this condition.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3539408

Citation

Warrington, R J., et al. "Cell-mediated Immune Responses to Artificial Food Additives in Chronic Urticaria." Clinical Allergy, vol. 16, no. 6, 1986, pp. 527-33.
Warrington RJ, Sauder PJ, McPhillips S. Cell-mediated immune responses to artificial food additives in chronic urticaria. Clin Allergy. 1986;16(6):527-33.
Warrington, R. J., Sauder, P. J., & McPhillips, S. (1986). Cell-mediated immune responses to artificial food additives in chronic urticaria. Clinical Allergy, 16(6), 527-33.
Warrington RJ, Sauder PJ, McPhillips S. Cell-mediated Immune Responses to Artificial Food Additives in Chronic Urticaria. Clin Allergy. 1986;16(6):527-33. PubMed PMID: 3539408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cell-mediated immune responses to artificial food additives in chronic urticaria. AU - Warrington,R J, AU - Sauder,P J, AU - McPhillips,S, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 527 EP - 33 JF - Clinical allergy JO - Clin. Allergy VL - 16 IS - 6 N2 - In some cases of chronic urticaria it is suspected that food additives such as tartrazine and sodium benzoate or salicylates may play a role in the pathogenesis of the condition. Since, at times, chronic urticaria may appear histologically similar to a mild cell-mediated immune response, the release of the T cell-derived lymphokine leucocyte inhibitory factor (LIF), in response to incubation with these additives and with acetylsalicylic acid (ASA), was measured in vitro using cells from normal controls, from patients with chronic urticaria with or without clinically associated additive sensitivity and from patients with asthma with or without associated ASA sensitivity. It was found that significant production of LIF occurred in response to tartrazine and sodium benzoate in those individuals with chronic additive induced urticaria. In addition, tartrazine caused LIF release from mononuclear cells of ASA-sensitive asthmatics. These results may indicate a possible role for additive-induced cell-mediated immune responses in the pathogenesis of some cases of chronic urticaria and suggest a potential diagnostic test for this condition. SN - 0009-9090 UR - https://www.unboundmedicine.com/medline/citation/3539408/Cell_mediated_immune_responses_to_artificial_food_additives_in_chronic_urticaria_ L2 - https://medlineplus.gov/hives.html DB - PRIME DP - Unbound Medicine ER -