Tags

Type your tag names separated by a space and hit enter

Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds.
Org Lett. 2022 04 22; 24(15):2910-2914.OL

Abstract

A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The approach provides a series of indole alkaloid compounds in moderate to excellent yields with good functional tolerance.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Qi H
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Chi D
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Chen S
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

MeSH

AlkenesAlkynesCatalysisIndole AlkaloidsIndolesPalladium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35394792

Citation

Qi, Hongbo, et al. "Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides With Alkynes to Construct Indole Alkaloid Scaffolds." Organic Letters, vol. 24, no. 15, 2022, pp. 2910-2914.
Qi H, Chi D, Chen S. Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds. Org Lett. 2022;24(15):2910-2914.
Qi, H., Chi, D., & Chen, S. (2022). Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds. Organic Letters, 24(15), 2910-2914. https://doi.org/10.1021/acs.orglett.2c00882
Qi H, Chi D, Chen S. Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides With Alkynes to Construct Indole Alkaloid Scaffolds. Org Lett. 2022 04 22;24(15):2910-2914. PubMed PMID: 35394792.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pd-Catalyzed C-H Functionalization of Indole-Containing Alkene-Tethered Aryl Halides with Alkynes To Construct Indole Alkaloid Scaffolds. AU - Qi,Hongbo, AU - Chi,Dongmei, AU - Chen,Shufeng, Y1 - 2022/04/08/ PY - 2022/4/9/pubmed PY - 2022/4/26/medline PY - 2022/4/8/entrez SP - 2910 EP - 2914 JF - Organic letters JO - Org Lett VL - 24 IS - 15 N2 - A convenient and straightforward approach for the construction of indole alkaloid scaffolds from indole-containing alkene-tethered aryl halides and alkynes through a sequential C-H activation, five-membered palladacycle formation, and alkyne insertion process has been described. The approach provides a series of indole alkaloid compounds in moderate to excellent yields with good functional tolerance. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/35394792/Pd_Catalyzed_C_H_Functionalization_of_Indole_Containing_Alkene_Tethered_Aryl_Halides_with_Alkynes_To_Construct_Indole_Alkaloid_Scaffolds_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓1]

Related Citations

More