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The basis of mink susceptibility to SARS-CoV-2 infection.
J Appl Genet. 2022 Sep; 63(3):543-555.JA

Abstract

Of all known airborne diseases in the twenty-first century, coronavirus disease 19 (COVID-19) has the highest infection and death rate. Over the past few decades, animal origin viral diseases, notably those of bats-linked, have increased many folds in humans with cross-species transmissions noted and the ongoing COVID-19 pandemic has emphasized the importance of understanding the evolution of natural hosts in response to viral pathogens. Cross-species transmissions are possible due to the possession of the angiotensin-converting enzyme 2 (ACE2) receptor in animals. ACE2 recognition by SARS-CoV-2 is a critical determinant of the host range, interspecies transmission, and viral pathogenesis. Thus, the phenomenon of breaking the cross-species barrier is mainly associated with mutations in the receptor-binding domain (RBD) of the spike (S) protein that interacts with ACE2. In this review, we raise the issue of cross-species transmission based on sequence alignment of S protein. Based on previous reports and our observations, we can conclude that the occurrence of one of two mutations D614G or Y453F is sufficient for infection of minks by SARS-CoV-2 from humans. Unfortunately, D614G is observed in the world's most common line of virus B.1.1.7 and the latest SARS-CoV-2 variants B.1.617.1, B.1.617.2, and B.1.617.3 too.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Poznań University of Life Sciences, Dojazd 11, 60-631, Poznań, Poland.Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479, Poznań, Poland.Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479, Poznań, Poland. andp@man.poznan.pl. Department of General and Endocrine Surgery and Gastroenterological Oncology, Poznań University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznań, Poland. andp@man.poznan.pl.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35396646

Citation

Barua, Avishak, et al. "The Basis of Mink Susceptibility to SARS-CoV-2 Infection." Journal of Applied Genetics, vol. 63, no. 3, 2022, pp. 543-555.
Barua A, Grot N, Plawski A. The basis of mink susceptibility to SARS-CoV-2 infection. J Appl Genet. 2022;63(3):543-555.
Barua, A., Grot, N., & Plawski, A. (2022). The basis of mink susceptibility to SARS-CoV-2 infection. Journal of Applied Genetics, 63(3), 543-555. https://doi.org/10.1007/s13353-022-00689-w
Barua A, Grot N, Plawski A. The Basis of Mink Susceptibility to SARS-CoV-2 Infection. J Appl Genet. 2022;63(3):543-555. PubMed PMID: 35396646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The basis of mink susceptibility to SARS-CoV-2 infection. AU - Barua,Avishak, AU - Grot,Natalia, AU - Plawski,Andrzej, Y1 - 2022/04/09/ PY - 2021/08/09/received PY - 2021/12/30/accepted PY - 2021/12/29/revised PY - 2022/4/10/pubmed PY - 2022/8/13/medline PY - 2022/4/9/entrez KW - Coronavirus KW - Cross-species infection KW - Minks KW - SARS-CoV-2 KW - Spike protein SP - 543 EP - 555 JF - Journal of applied genetics JO - J Appl Genet VL - 63 IS - 3 N2 - Of all known airborne diseases in the twenty-first century, coronavirus disease 19 (COVID-19) has the highest infection and death rate. Over the past few decades, animal origin viral diseases, notably those of bats-linked, have increased many folds in humans with cross-species transmissions noted and the ongoing COVID-19 pandemic has emphasized the importance of understanding the evolution of natural hosts in response to viral pathogens. Cross-species transmissions are possible due to the possession of the angiotensin-converting enzyme 2 (ACE2) receptor in animals. ACE2 recognition by SARS-CoV-2 is a critical determinant of the host range, interspecies transmission, and viral pathogenesis. Thus, the phenomenon of breaking the cross-species barrier is mainly associated with mutations in the receptor-binding domain (RBD) of the spike (S) protein that interacts with ACE2. In this review, we raise the issue of cross-species transmission based on sequence alignment of S protein. Based on previous reports and our observations, we can conclude that the occurrence of one of two mutations D614G or Y453F is sufficient for infection of minks by SARS-CoV-2 from humans. Unfortunately, D614G is observed in the world's most common line of virus B.1.1.7 and the latest SARS-CoV-2 variants B.1.617.1, B.1.617.2, and B.1.617.3 too. SN - 2190-3883 UR - https://www.unboundmedicine.com/medline/citation/35396646/The_basis_of_mink_susceptibility_to_SARS_CoV_2_infection_ DB - PRIME DP - Unbound Medicine ER -