TY - JOUR T1 - Ex vivo-In vivo correlation of retinol stratum corneum penetration studies by confocal Raman microspectroscopy and tape stripping. AU - Krombholz,Richard, AU - Fressle,Stefanie, AU - Lunter,Dominique, Y1 - 2022/05/16/ PY - 2022/04/06/revised PY - 2022/02/23/received PY - 2022/04/06/accepted PY - 2022/4/10/pubmed PY - 2022/7/6/medline PY - 2022/4/9/entrez KW - confocal Raman KW - delivery KW - dermatology KW - retinol KW - skin barrier KW - skin penetration KW - spectroscopy SP - 299 EP - 308 JF - International journal of cosmetic science JO - Int J Cosmet Sci VL - 44 IS - 3 N2 - Skin penetration studies of topically applied drugs are a challenging topic in the development of semisolid formulations. The most commonly used methods can be differentiated by their character into ex vivo/in vivo, invasive/non-invasive and offline/in-line measurements. In this study, we compare ex vivo tape stripping, an invasive technique, which is often used, to confocal Raman microspectroscopy (CRM), ex and in vivo, to establish a correlation between those methods. Retinol was used as a model drug, applied in an oil-in-water emulsion, to compare the skin penetration profiles obtained by the different methods. SN - 1468-2494 UR - https://www.unboundmedicine.com/medline/citation/35396727/Ex_vivo_In_vivo_correlation_of_retinol_stratum_corneum_penetration_studies_by_confocal_Raman_microspectroscopy_and_tape_stripping_ DB - PRIME DP - Unbound Medicine ER -