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Coffee consumption is not associated with the risk of gastric cancer: An updated systematic review and meta-analysis of prospective cohort studies.
Nutr Res. 2022 06; 102:35-44.NR

Abstract

The results from epidemiological studies on the relationship between coffee consumption and gastric cancer risk are inconsistent and inconclusive. Based on the previous studies, we hypothesized that coffee consumption was not associated with the risk of gastric cancer. We aimed to test this hypothesis by conducting a meta-analysis to systematically review and quantify the relationship between coffee consumption and the risk of gastric cancer. Relevant prospective cohort studies were identified by a search of PubMed and Embase up to March 2021. A total of 18 independent prospective cohorts from 15 studies involving 1,608,760 participants and 3898 gastric cancer cases were included in this meta-analysis. A nonsignificant association with a pooled relative risk (RR) of 1.11 (95% confidence interval [CI], 0.99-1.25) was shown between coffee intake and the risk of gastric cancer. The dose-response analysis also suggested no significant effect on the risk of gastric cancer per 1 cup/d increment in coffee consumption (RR = 1.00; 95% CI, 0.99-1.01). No nonlinear association of gastric cancer risk with coffee consumption was found (P for nonlinearity = .17). In the subgroup analyses, significantly increased risk of gastric cancer was detected in the studies conducted in the United States (RR = 1.28; 95% CI, 1.03-1.58). In conclusion, coffee consumption had no effect on the risk of gastric cancer. However, the effect of coffee intake on persons in the United States must be further evaluated by additional high-quality and large-scale cohort studies.

Authors+Show Affiliations

College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, China.College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, China.College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35405601

Citation

Song, Haizhao, et al. "Coffee Consumption Is Not Associated With the Risk of Gastric Cancer: an Updated Systematic Review and Meta-analysis of Prospective Cohort Studies." Nutrition Research (New York, N.Y.), vol. 102, 2022, pp. 35-44.
Song H, Shen X, Chu Q, et al. Coffee consumption is not associated with the risk of gastric cancer: An updated systematic review and meta-analysis of prospective cohort studies. Nutr Res. 2022;102:35-44.
Song, H., Shen, X., Chu, Q., & Zheng, X. (2022). Coffee consumption is not associated with the risk of gastric cancer: An updated systematic review and meta-analysis of prospective cohort studies. Nutrition Research (New York, N.Y.), 102, 35-44. https://doi.org/10.1016/j.nutres.2022.03.002
Song H, et al. Coffee Consumption Is Not Associated With the Risk of Gastric Cancer: an Updated Systematic Review and Meta-analysis of Prospective Cohort Studies. Nutr Res. 2022;102:35-44. PubMed PMID: 35405601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption is not associated with the risk of gastric cancer: An updated systematic review and meta-analysis of prospective cohort studies. AU - Song,Haizhao, AU - Shen,Xinchun, AU - Chu,Qiang, AU - Zheng,Xiaodong, Y1 - 2022/03/14/ PY - 2021/09/01/received PY - 2022/03/02/revised PY - 2022/03/08/accepted PY - 2022/4/12/pubmed PY - 2022/5/18/medline PY - 2022/4/11/entrez KW - Coffee consumption KW - Dose-response analysis KW - Gastric cancer KW - Meta-analysis KW - Prospective cohort studies SP - 35 EP - 44 JF - Nutrition research (New York, N.Y.) JO - Nutr Res VL - 102 N2 - The results from epidemiological studies on the relationship between coffee consumption and gastric cancer risk are inconsistent and inconclusive. Based on the previous studies, we hypothesized that coffee consumption was not associated with the risk of gastric cancer. We aimed to test this hypothesis by conducting a meta-analysis to systematically review and quantify the relationship between coffee consumption and the risk of gastric cancer. Relevant prospective cohort studies were identified by a search of PubMed and Embase up to March 2021. A total of 18 independent prospective cohorts from 15 studies involving 1,608,760 participants and 3898 gastric cancer cases were included in this meta-analysis. A nonsignificant association with a pooled relative risk (RR) of 1.11 (95% confidence interval [CI], 0.99-1.25) was shown between coffee intake and the risk of gastric cancer. The dose-response analysis also suggested no significant effect on the risk of gastric cancer per 1 cup/d increment in coffee consumption (RR = 1.00; 95% CI, 0.99-1.01). No nonlinear association of gastric cancer risk with coffee consumption was found (P for nonlinearity = .17). In the subgroup analyses, significantly increased risk of gastric cancer was detected in the studies conducted in the United States (RR = 1.28; 95% CI, 1.03-1.58). In conclusion, coffee consumption had no effect on the risk of gastric cancer. However, the effect of coffee intake on persons in the United States must be further evaluated by additional high-quality and large-scale cohort studies. SN - 1879-0739 UR - https://www.unboundmedicine.com/medline/citation/35405601/Coffee_consumption_is_not_associated_with_the_risk_of_gastric_cancer:_An_updated_systematic_review_and_meta_analysis_of_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(22)00018-5 DB - PRIME DP - Unbound Medicine ER -