Tags

Type your tag names separated by a space and hit enter

Bronchoconstriction due to isocapnic cold air inhalation minimally influences bronchial hyperresponsiveness to methacholine in asthmatic subjects.
Bull Eur Physiopathol Respir. 1986 Sep-Oct; 22(5):473-7.BE

Abstract

The aim of this study was to investigate if bronchial hyperresponsiveness to methacholine could be influenced by a previous bronchoconstriction due to isocapnic inhalation of cold air. Twelve adult asthmatic subjects in a clinical steady state were seen on four different days in a randomized way according to three different sequences. After assessment of spirometry, bronchial responsiveness to inhaled methacholine was determined on each occasion by the provocative concentration causing a fall of 20% in FEV1 (PC20). On two occasions, the methacholine test was preceded by the inhalation of dry cold air which caused significant (greater than 20% change in FEV1) bronchoconstriction. The methacholine test was performed after functional recovery. There was a significant (t = 2.53; p less than 0.05) but minimal (mean changes of 0.65 single two-fold concentration difference) reduction in PC20 after cold air inhalation. It is concluded that cold air-induced bronchoconstriction causes significant but minimal changes in bronchial responsiveness to methacholine in asthmatic subjects.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3542088

Citation

Malo, J L., et al. "Bronchoconstriction Due to Isocapnic Cold Air Inhalation Minimally Influences Bronchial Hyperresponsiveness to Methacholine in Asthmatic Subjects." Bulletin Europeen De Physiopathologie Respiratoire, vol. 22, no. 5, 1986, pp. 473-7.
Malo JL, Cartier A, L'Archevêque J, et al. Bronchoconstriction due to isocapnic cold air inhalation minimally influences bronchial hyperresponsiveness to methacholine in asthmatic subjects. Bull Eur Physiopathol Respir. 1986;22(5):473-7.
Malo, J. L., Cartier, A., L'Archevêque, J., Ghezzo, H., & Martin, R. R. (1986). Bronchoconstriction due to isocapnic cold air inhalation minimally influences bronchial hyperresponsiveness to methacholine in asthmatic subjects. Bulletin Europeen De Physiopathologie Respiratoire, 22(5), 473-7.
Malo JL, et al. Bronchoconstriction Due to Isocapnic Cold Air Inhalation Minimally Influences Bronchial Hyperresponsiveness to Methacholine in Asthmatic Subjects. Bull Eur Physiopathol Respir. 1986 Sep-Oct;22(5):473-7. PubMed PMID: 3542088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchoconstriction due to isocapnic cold air inhalation minimally influences bronchial hyperresponsiveness to methacholine in asthmatic subjects. AU - Malo,J L, AU - Cartier,A, AU - L'Archevêque,J, AU - Ghezzo,H, AU - Martin,R R, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 473 EP - 7 JF - Bulletin europeen de physiopathologie respiratoire JO - Bull Eur Physiopathol Respir VL - 22 IS - 5 N2 - The aim of this study was to investigate if bronchial hyperresponsiveness to methacholine could be influenced by a previous bronchoconstriction due to isocapnic inhalation of cold air. Twelve adult asthmatic subjects in a clinical steady state were seen on four different days in a randomized way according to three different sequences. After assessment of spirometry, bronchial responsiveness to inhaled methacholine was determined on each occasion by the provocative concentration causing a fall of 20% in FEV1 (PC20). On two occasions, the methacholine test was preceded by the inhalation of dry cold air which caused significant (greater than 20% change in FEV1) bronchoconstriction. The methacholine test was performed after functional recovery. There was a significant (t = 2.53; p less than 0.05) but minimal (mean changes of 0.65 single two-fold concentration difference) reduction in PC20 after cold air inhalation. It is concluded that cold air-induced bronchoconstriction causes significant but minimal changes in bronchial responsiveness to methacholine in asthmatic subjects. SN - 0395-3890 UR - https://www.unboundmedicine.com/medline/citation/3542088/Bronchoconstriction_due_to_isocapnic_cold_air_inhalation_minimally_influences_bronchial_hyperresponsiveness_to_methacholine_in_asthmatic_subjects_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -