Tags

Type your tag names separated by a space and hit enter

Effect of two periods with intensified insulin treatment on B-cell function during the first 18 months of type 1 (insulin-dependent) diabetes mellitus.
Diabete Metab. 1986 Oct; 12(5):256-60.DM

Abstract

Fifteen consecutive type 1 (insulin-dependent) diabetics were randomized within 24 hrs of diagnosis of the disease into two groups for treatment: group A (N = 9) was treated conventionally with one or two daily doses of insulin, group B (N = 6) was treated with nine daily injections of fast-acting insulin for ten days after diagnosis and for 7 days after 15 months duration of diabetes. For remaining time group B was treated conventionally like group A. The mean diurnal blood glucose concentration during the initial ten days of insulin treatment was 11.7 +/- 0.5 mmol/l (mean +/- SEM) in group A and 6.4 +/- 0.3 mmol/l in group B (P less than 0.01) and 6.0 +/- 0.3 mmol/l in group B during the 7 days with intensified treatment 15 months later. B-cell function was assessed from the C-peptide response to a standard meal 17 and 14 days and 3, 6, 9, 12, 15 and 18 months after start of insulin treatment. After 14 days the C-peptide response was significantly higher (60%) in group B than in group A (P less than 0.05). The second period with strict control improved B-cell function in 4 out of 5 patients with B-cell function. At no test other than after 14 days was there any difference in B-cell function between the groups. Short-term improvement of glycaemic control at onset of disease and after the remission period seem without effect on the long-term outcome of B-cell function in type 1 (insulin-dependent) diabetics.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3542618

Citation

Krarup, T, and S Madsbad. "Effect of Two Periods With Intensified Insulin Treatment On B-cell Function During the First 18 Months of Type 1 (insulin-dependent) Diabetes Mellitus." Diabete & Metabolisme, vol. 12, no. 5, 1986, pp. 256-60.
Krarup T, Madsbad S. Effect of two periods with intensified insulin treatment on B-cell function during the first 18 months of type 1 (insulin-dependent) diabetes mellitus. Diabete Metab. 1986;12(5):256-60.
Krarup, T., & Madsbad, S. (1986). Effect of two periods with intensified insulin treatment on B-cell function during the first 18 months of type 1 (insulin-dependent) diabetes mellitus. Diabete & Metabolisme, 12(5), 256-60.
Krarup T, Madsbad S. Effect of Two Periods With Intensified Insulin Treatment On B-cell Function During the First 18 Months of Type 1 (insulin-dependent) Diabetes Mellitus. Diabete Metab. 1986;12(5):256-60. PubMed PMID: 3542618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of two periods with intensified insulin treatment on B-cell function during the first 18 months of type 1 (insulin-dependent) diabetes mellitus. AU - Krarup,T, AU - Madsbad,S, PY - 1986/10/1/pubmed PY - 2000/3/11/medline PY - 1986/10/1/entrez SP - 256 EP - 60 JF - Diabete & metabolisme JO - Diabete Metab VL - 12 IS - 5 N2 - Fifteen consecutive type 1 (insulin-dependent) diabetics were randomized within 24 hrs of diagnosis of the disease into two groups for treatment: group A (N = 9) was treated conventionally with one or two daily doses of insulin, group B (N = 6) was treated with nine daily injections of fast-acting insulin for ten days after diagnosis and for 7 days after 15 months duration of diabetes. For remaining time group B was treated conventionally like group A. The mean diurnal blood glucose concentration during the initial ten days of insulin treatment was 11.7 +/- 0.5 mmol/l (mean +/- SEM) in group A and 6.4 +/- 0.3 mmol/l in group B (P less than 0.01) and 6.0 +/- 0.3 mmol/l in group B during the 7 days with intensified treatment 15 months later. B-cell function was assessed from the C-peptide response to a standard meal 17 and 14 days and 3, 6, 9, 12, 15 and 18 months after start of insulin treatment. After 14 days the C-peptide response was significantly higher (60%) in group B than in group A (P less than 0.05). The second period with strict control improved B-cell function in 4 out of 5 patients with B-cell function. At no test other than after 14 days was there any difference in B-cell function between the groups. Short-term improvement of glycaemic control at onset of disease and after the remission period seem without effect on the long-term outcome of B-cell function in type 1 (insulin-dependent) diabetics. SN - 0338-1684 UR - https://www.unboundmedicine.com/medline/citation/3542618/Effect_of_two_periods_with_intensified_insulin_treatment_on_B_cell_function_during_the_first_18_months_of_type_1__insulin_dependent__diabetes_mellitus_ L2 - https://www.diseaseinfosearch.org/result/8214 DB - PRIME DP - Unbound Medicine ER -