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Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review.
Climacteric. 2022 Apr 19 [Online ahead of print]C

Abstract

Systemic lupus erythematosus (SLE) primarily affects women, who may need hormone therapy (HT) in menopause. There is, however, some concern as to its efficacy and safety. This systematic review aimed to determine the effect of HT on the activity of SLE and its safety. The study was a qualitative systematic review. Research was conducted with data retrieved from Embase, MEDLINE and Cochrane databases using MESH terms up to April 2021, with no bar on date or language. Sixteen studies were selected for analysis. Most of them showed HT to be effective in the treatment of menopausal symptoms with no impact in SLE activity, but one randomized clinical trial showed an increase in the number of thrombotic events. The present systematic review demonstrated the efficacy of HT for treating the menopausal symptoms of SLE patients. The risk of flare and thrombosis seems to be very low.

Authors+Show Affiliations

Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35438053

Citation

Soares-Jr, J M., et al. "Hormone Therapy Effect On Menopausal Systemic Lupus Erythematosus Patients: a Systematic Review." Climacteric : the Journal of the International Menopause Society, 2022, pp. 1-7.
Soares-Jr JM, Espósito Sorpreso IC, Nunes Curado JF, et al. Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review. Climacteric. 2022.
Soares-Jr, J. M., Espósito Sorpreso, I. C., Nunes Curado, J. F., Ferreira Filho, E. S., Dos Santos Simões, R., Bonfá, E., Silva, C. A., & Baracat, E. C. (2022). Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review. Climacteric : the Journal of the International Menopause Society, 1-7. https://doi.org/10.1080/13697137.2022.2050205
Soares-Jr JM, et al. Hormone Therapy Effect On Menopausal Systemic Lupus Erythematosus Patients: a Systematic Review. Climacteric. 2022 Apr 19;1-7. PubMed PMID: 35438053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormone therapy effect on menopausal systemic lupus erythematosus patients: a systematic review. AU - Soares-Jr,J M, AU - Espósito Sorpreso,I C, AU - Nunes Curado,J F, AU - Ferreira Filho,E S, AU - Dos Santos Simões,R, AU - Bonfá,E, AU - Silva,C A, AU - Baracat,E C, Y1 - 2022/04/19/ PY - 2022/4/19/entrez PY - 2022/4/20/pubmed PY - 2022/4/20/medline KW - Systemic lupus erythematosus KW - hormone replacement therapy KW - hormone therapy KW - menopause SP - 1 EP - 7 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric N2 - Systemic lupus erythematosus (SLE) primarily affects women, who may need hormone therapy (HT) in menopause. There is, however, some concern as to its efficacy and safety. This systematic review aimed to determine the effect of HT on the activity of SLE and its safety. The study was a qualitative systematic review. Research was conducted with data retrieved from Embase, MEDLINE and Cochrane databases using MESH terms up to April 2021, with no bar on date or language. Sixteen studies were selected for analysis. Most of them showed HT to be effective in the treatment of menopausal symptoms with no impact in SLE activity, but one randomized clinical trial showed an increase in the number of thrombotic events. The present systematic review demonstrated the efficacy of HT for treating the menopausal symptoms of SLE patients. The risk of flare and thrombosis seems to be very low. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35438053/Hormone_therapy_effect_on_menopausal_systemic_lupus_erythematosus_patients:_a_systematic_review. L2 - https://www.tandfonline.com/doi/full/10.1080/13697137.2022.2050205 DB - PRIME DP - Unbound Medicine ER -