Tags

Type your tag names separated by a space and hit enter

The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse.
Climacteric. 2022 08; 25(4):407-412.C

Abstract

OBJECTIVE

This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (Loxl1) gene and its association with pelvic organ prolapse (POP) in Brazilian women and determine risk factors for POP development.

METHODS

The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with p < 0.05 for significance.

RESULTS

A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42).

CONCLUSION

No association was detected between rs2165241 of the Loxl1 gene and POP.

Authors+Show Affiliations

Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.Department of Urogynecology and Vaginal Surgery, Centro Universitário FMABC, Santo André, Brazil.Department of Morphology and Physiology, Centro Universitário FMABC, Santo André, Brazil.Department of Urogynecology and Reconstructive Pelvic Surgery, Universidade Federal de São Paulo, São Paulo, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35440244

Citation

Costa E Silva, C L., et al. "The Rs2165241 Polymorphism of the Loxl1 Gene in Postmenopausal Women With Pelvic Organ Prolapse." Climacteric : the Journal of the International Menopause Society, vol. 25, no. 4, 2022, pp. 407-412.
Costa E Silva CL, Bortolini MAT, Batista NC, et al. The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse. Climacteric. 2022;25(4):407-412.
Costa E Silva, C. L., Bortolini, M. A. T., Batista, N. C., Silva, R. S. P., Teixeira, J. B., Oliveira, É., Souto, R. P., & Castro, R. A. (2022). The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse. Climacteric : the Journal of the International Menopause Society, 25(4), 407-412. https://doi.org/10.1080/13697137.2022.2058392
Costa E Silva CL, et al. The Rs2165241 Polymorphism of the Loxl1 Gene in Postmenopausal Women With Pelvic Organ Prolapse. Climacteric. 2022;25(4):407-412. PubMed PMID: 35440244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The rs2165241 polymorphism of the Loxl1 gene in postmenopausal women with pelvic organ prolapse. AU - Costa E Silva,C L, AU - Bortolini,M A T, AU - Batista,N C, AU - Silva,R S P, AU - Teixeira,J B, AU - Oliveira,É, AU - Souto,R P, AU - Castro,R A, Y1 - 2022/04/20/ PY - 2022/4/21/pubmed PY - 2022/7/12/medline PY - 2022/4/20/entrez KW - Pelvic organ prolapse KW - elastic fibers KW - elastin KW - extracellular matrix KW - lysyl oxidase-like 1 KW - polymorphism SP - 407 EP - 412 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric VL - 25 IS - 4 N2 - OBJECTIVE: This study aimed to verify the presence of polymorphism rs2165241 of the lysyl oxidase-like 1 (Loxl1) gene and its association with pelvic organ prolapse (POP) in Brazilian women and determine risk factors for POP development. METHODS: The study was previously approved by the local research and ethics board. Postmenopausal women were included and divided into POP (stages III and IV) and control (stages 0 and I) groups. Peripheral blood samples were collected, and the DNA sequence of interest was analyzed by real-time reverse-transcriptase polymerase chain reaction. We used logistic regression and considered a recessive model of inheritance for the analysis, with p < 0.05 for significance. RESULTS: A total of 836 women were assessed: 426 POP cases and 410 controls. The frequencies of CC, CT and TT genotypes were similar in both groups. Age (odds ratio [OR] = 1.1, 95% confidence interval [CI] = 1.07; 1.14), number of vaginal births (OR = 17.06, 95% CI = 5.94; 48.97), family history (OR = 2.87, 95% CI = 1.57; 5.22) and weight of largest newborn (OR = 1.001, 95% CI = 1.0003; 1.001) were independent risk factors for POP, while multiple cesarean sections (two or more) was protective (OR = 0.17, 95% CI = 0.07; 0.42). CONCLUSION: No association was detected between rs2165241 of the Loxl1 gene and POP. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35440244/The_rs2165241_polymorphism_of_the_Loxl1_gene_in_postmenopausal_women_with_pelvic_organ_prolapse. DB - PRIME DP - Unbound Medicine ER -