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Evaluation of monitoring antibodies to PGL-I in armadillos experimentally infected with M. leprae.
Int J Lepr Other Mycobact Dis. 1986 Dec; 54(4):556-9.IJ

Abstract

An enzyme-linked immunosorbent assay (ELISA) for IgM antibodies to the phenolic glycolipid-I antigen of Mycobacterium leprae was evaluated for efficacy in monitoring armadillos experimentally infected with the bacillus. IgM antibodies were detected in armadillos from 186 days after experimental infection until the animals were sacrificed. The ELISA demonstrated the establishment of infection earlier and more reliably than the histologic methods previously applied. Satisfactory yields of M. leprae from individual armadillos could be predicted 97% of the time, and the technique may be useful in identifying appropriate harvest times or resistance among armadillos. The ELISA seems to be a valuable adjunct for managing experimental infections of M. leprae in armadillos.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3546545

Citation

Truman, R W., et al. "Evaluation of Monitoring Antibodies to PGL-I in Armadillos Experimentally Infected With M. Leprae." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 54, no. 4, 1986, pp. 556-9.
Truman RW, Morales MJ, Shannon EJ, et al. Evaluation of monitoring antibodies to PGL-I in armadillos experimentally infected with M. leprae. Int J Lepr Other Mycobact Dis. 1986;54(4):556-9.
Truman, R. W., Morales, M. J., Shannon, E. J., & Hastings, R. C. (1986). Evaluation of monitoring antibodies to PGL-I in armadillos experimentally infected with M. leprae. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 54(4), 556-9.
Truman RW, et al. Evaluation of Monitoring Antibodies to PGL-I in Armadillos Experimentally Infected With M. Leprae. Int J Lepr Other Mycobact Dis. 1986;54(4):556-9. PubMed PMID: 3546545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of monitoring antibodies to PGL-I in armadillos experimentally infected with M. leprae. AU - Truman,R W, AU - Morales,M J, AU - Shannon,E J, AU - Hastings,R C, PY - 1986/12/1/pubmed PY - 1986/12/1/medline PY - 1986/12/1/entrez SP - 556 EP - 9 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 54 IS - 4 N2 - An enzyme-linked immunosorbent assay (ELISA) for IgM antibodies to the phenolic glycolipid-I antigen of Mycobacterium leprae was evaluated for efficacy in monitoring armadillos experimentally infected with the bacillus. IgM antibodies were detected in armadillos from 186 days after experimental infection until the animals were sacrificed. The ELISA demonstrated the establishment of infection earlier and more reliably than the histologic methods previously applied. Satisfactory yields of M. leprae from individual armadillos could be predicted 97% of the time, and the technique may be useful in identifying appropriate harvest times or resistance among armadillos. The ELISA seems to be a valuable adjunct for managing experimental infections of M. leprae in armadillos. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3546545/Evaluation_of_monitoring_antibodies_to_PGL_I_in_armadillos_experimentally_infected_with_M__leprae_ DB - PRIME DP - Unbound Medicine ER -