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Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study.
J Trop Med Hyg. 1987 Feb; 90(1):9-12.JT

Abstract

Metronidazole, tinidazole and ornidazole were compared in patients treated for Entamoeba histolytica or Giardia lamblia intestinal infections. Only patients with three positive stool specimens for trophozoites and/or cysts of E. histolytica or G. lamblia by the merthiolate iodine formaldehyde (MIFC) technique were included. Criteria for cure were at least 10 negative stool specimens over 3 weeks after completing therapy. Fifty-three male patients (aged 9-65 years) had E. histolytica infection. Seventeen received metronidazole (1.5 g daily for 10 days), 18 tinidazole (1.5 g daily for 10 days) and 18 ornidazole (1 g daily for 10 days). Metronidazole yielded 88%, tinidazole 67% and ornidazole 94% cure rates. Side reactions were minor. Eighty patients had G. lamblia infection, of whom 20 received metronidazole (0.5 g daily for 10 days), 30 tinidazole (single 2 g dose) and 30 ornidazole (single 1 g dose). Cure rates were 95% for metronidazole, 90% for tinidazole and 97% for ornidazole with no side reactions.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3546716

Citation

Bassily, S, et al. "Treatment of Intestinal E. Histolytica and G. Lamblia With Metronidazole, Tinidazole and Ornidazole: a Comparative Study." The Journal of Tropical Medicine and Hygiene, vol. 90, no. 1, 1987, pp. 9-12.
Bassily S, Farid Z, el-Masry NA, et al. Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study. J Trop Med Hyg. 1987;90(1):9-12.
Bassily, S., Farid, Z., el-Masry, N. A., & Mikhail, E. M. (1987). Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study. The Journal of Tropical Medicine and Hygiene, 90(1), 9-12.
Bassily S, et al. Treatment of Intestinal E. Histolytica and G. Lamblia With Metronidazole, Tinidazole and Ornidazole: a Comparative Study. J Trop Med Hyg. 1987;90(1):9-12. PubMed PMID: 3546716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of intestinal E. histolytica and G. lamblia with metronidazole, tinidazole and ornidazole: a comparative study. AU - Bassily,S, AU - Farid,Z, AU - el-Masry,N A, AU - Mikhail,E M, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 9 EP - 12 JF - The Journal of tropical medicine and hygiene JO - J Trop Med Hyg VL - 90 IS - 1 N2 - Metronidazole, tinidazole and ornidazole were compared in patients treated for Entamoeba histolytica or Giardia lamblia intestinal infections. Only patients with three positive stool specimens for trophozoites and/or cysts of E. histolytica or G. lamblia by the merthiolate iodine formaldehyde (MIFC) technique were included. Criteria for cure were at least 10 negative stool specimens over 3 weeks after completing therapy. Fifty-three male patients (aged 9-65 years) had E. histolytica infection. Seventeen received metronidazole (1.5 g daily for 10 days), 18 tinidazole (1.5 g daily for 10 days) and 18 ornidazole (1 g daily for 10 days). Metronidazole yielded 88%, tinidazole 67% and ornidazole 94% cure rates. Side reactions were minor. Eighty patients had G. lamblia infection, of whom 20 received metronidazole (0.5 g daily for 10 days), 30 tinidazole (single 2 g dose) and 30 ornidazole (single 1 g dose). Cure rates were 95% for metronidazole, 90% for tinidazole and 97% for ornidazole with no side reactions. SN - 0022-5304 UR - https://www.unboundmedicine.com/medline/citation/3546716/Treatment_of_intestinal_E__histolytica_and_G__lamblia_with_metronidazole_tinidazole_and_ornidazole:_a_comparative_study_ L2 - https://medlineplus.gov/giardiainfections.html DB - PRIME DP - Unbound Medicine ER -