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Experimental basis for the use of bisphosphonates in Paget's disease of bone.

Abstract

Geminal bisphosphonates are a new class of drugs recently developed. They are characterized by a phosphorus-carbon-phosphorus (PCP) bond and are thus analogs of pyrophosphate. The bind strongly to hydroxyapatite crystals and inhibit in vitro both their formation and dissolution. In vivo they inhibit soft tissue calcification and in some instances normal calcification. Bone resorption is also inhibited. The mechanism of action for the inhibition of calcification is probably the inhibition of calcium phosphate crystal growth. However, the mode of action on bone resorption is not yet known but is more likely to be cellular. These properties have been used in man to prevent heterotopic calcification, to retard dental calculus, and to slow down bone resorption in conditions such as Paget's disease, tumoral bone disease, and osteoporotic immobilization.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3549097

Citation

Fleisch, H. "Experimental Basis for the Use of Bisphosphonates in Paget's Disease of Bone." Clinical Orthopaedics and Related Research, 1987, pp. 72-8.
Fleisch H. Experimental basis for the use of bisphosphonates in Paget's disease of bone. Clin Orthop Relat Res. 1987.
Fleisch, H. (1987). Experimental basis for the use of bisphosphonates in Paget's disease of bone. Clinical Orthopaedics and Related Research, (217), 72-8.
Fleisch H. Experimental Basis for the Use of Bisphosphonates in Paget's Disease of Bone. Clin Orthop Relat Res. 1987;(217)72-8. PubMed PMID: 3549097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental basis for the use of bisphosphonates in Paget's disease of bone. A1 - Fleisch,H, PY - 1987/4/1/pubmed PY - 1987/4/1/medline PY - 1987/4/1/entrez SP - 72 EP - 8 JF - Clinical orthopaedics and related research JO - Clin Orthop Relat Res IS - 217 N2 - Geminal bisphosphonates are a new class of drugs recently developed. They are characterized by a phosphorus-carbon-phosphorus (PCP) bond and are thus analogs of pyrophosphate. The bind strongly to hydroxyapatite crystals and inhibit in vitro both their formation and dissolution. In vivo they inhibit soft tissue calcification and in some instances normal calcification. Bone resorption is also inhibited. The mechanism of action for the inhibition of calcification is probably the inhibition of calcium phosphate crystal growth. However, the mode of action on bone resorption is not yet known but is more likely to be cellular. These properties have been used in man to prevent heterotopic calcification, to retard dental calculus, and to slow down bone resorption in conditions such as Paget's disease, tumoral bone disease, and osteoporotic immobilization. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/3549097/Experimental_basis_for_the_use_of_bisphosphonates_in_Paget's_disease_of_bone_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3549097.ui DB - PRIME DP - Unbound Medicine ER -