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C-peptide in diabetes mellitus treated with insulin. A 3-year epidemiological study on the island of Falster, Denmark.
Diabetes Res. 1986 Nov; 3(9):475-8.DR

Abstract

In a 3 yr prospective epidemiological study of 227 insulin-treated diabetics the clinical value of fasting C-peptide measurements for discriminating between insulin dependence and non-insulin dependence was assessed. A significant difference (p less than 0.01) in fasting C-peptide secretion was found between diabetics with an early onset age (less than 30 yr) and a late onset age (greater than or equal to 30 yr). Among diabetics with a late onset age (n = 124) 45% were classified as non-insulin dependent according to fasting C-peptide levels (greater than 0.40 pmol/ml) and characterized by overweight. Diabetics with C-peptide concentrations less than 20 pmol/ml were characterized by an early onset of diabetes mellitus (less than 30 yr), the duration of diabetes mellitus (greater than 5 yr), slight deviation from ideal weight, development of insulin antibodies and high daily insulin dosage. Among the 57 diabetics with a C-peptide level greater than 0.40 pmol/ml 31 accepted and could maintain good metabolic control in a period of 3 yr after change from treatment with insulin to treatment with oral hypoglycaemic agent and diet or diet regime alone. It is concluded that measurement of fasting C-peptide is of additional clinical importance for the choice of treatment of diabetics.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3549123

Citation

Nielsen, N V., and B Tronier. "C-peptide in Diabetes Mellitus Treated With Insulin. a 3-year Epidemiological Study On the Island of Falster, Denmark." Diabetes Research (Edinburgh, Scotland), vol. 3, no. 9, 1986, pp. 475-8.
Nielsen NV, Tronier B. C-peptide in diabetes mellitus treated with insulin. A 3-year epidemiological study on the island of Falster, Denmark. Diabetes Res. 1986;3(9):475-8.
Nielsen, N. V., & Tronier, B. (1986). C-peptide in diabetes mellitus treated with insulin. A 3-year epidemiological study on the island of Falster, Denmark. Diabetes Research (Edinburgh, Scotland), 3(9), 475-8.
Nielsen NV, Tronier B. C-peptide in Diabetes Mellitus Treated With Insulin. a 3-year Epidemiological Study On the Island of Falster, Denmark. Diabetes Res. 1986;3(9):475-8. PubMed PMID: 3549123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-peptide in diabetes mellitus treated with insulin. A 3-year epidemiological study on the island of Falster, Denmark. AU - Nielsen,N V, AU - Tronier,B, PY - 1986/11/1/pubmed PY - 1986/11/1/medline PY - 1986/11/1/entrez SP - 475 EP - 8 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res VL - 3 IS - 9 N2 - In a 3 yr prospective epidemiological study of 227 insulin-treated diabetics the clinical value of fasting C-peptide measurements for discriminating between insulin dependence and non-insulin dependence was assessed. A significant difference (p less than 0.01) in fasting C-peptide secretion was found between diabetics with an early onset age (less than 30 yr) and a late onset age (greater than or equal to 30 yr). Among diabetics with a late onset age (n = 124) 45% were classified as non-insulin dependent according to fasting C-peptide levels (greater than 0.40 pmol/ml) and characterized by overweight. Diabetics with C-peptide concentrations less than 20 pmol/ml were characterized by an early onset of diabetes mellitus (less than 30 yr), the duration of diabetes mellitus (greater than 5 yr), slight deviation from ideal weight, development of insulin antibodies and high daily insulin dosage. Among the 57 diabetics with a C-peptide level greater than 0.40 pmol/ml 31 accepted and could maintain good metabolic control in a period of 3 yr after change from treatment with insulin to treatment with oral hypoglycaemic agent and diet or diet regime alone. It is concluded that measurement of fasting C-peptide is of additional clinical importance for the choice of treatment of diabetics. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/3549123/C_peptide_in_diabetes_mellitus_treated_with_insulin__A_3_year_epidemiological_study_on_the_island_of_Falster_Denmark_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -