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Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants.
J Am Dent Assoc 1987; 114(4):461-7JA

Abstract

Intensive chemoradiotherapy damages the mucosal barrier of the mouth and throat and is often associated with severe oral inflammation and infection. This study examined the use of a 0.12% chlorhexidine gluconate mouthrinse for prophylaxis against oral complications in patients receiving bone marrow transplants. Use of chlorhexidine mouthrinse produced reductions in oral soft tissue disease and oral microbial burden, including a significant decrease in oral mucositis and Candida infections. The advantage for patients undergoing intensive antineoplastic therapy, and potentially for other immunocompromised patients susceptible to oral infections, was studied.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3549834

Citation

Ferretti, G A., et al. "Chlorhexidine for Prophylaxis Against Oral Infections and Associated Complications in Patients Receiving Bone Marrow Transplants." Journal of the American Dental Association (1939), vol. 114, no. 4, 1987, pp. 461-7.
Ferretti GA, Ash RC, Brown AT, et al. Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants. J Am Dent Assoc. 1987;114(4):461-7.
Ferretti, G. A., Ash, R. C., Brown, A. T., Largent, B. M., Kaplan, A., & Lillich, T. T. (1987). Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants. Journal of the American Dental Association (1939), 114(4), pp. 461-7.
Ferretti GA, et al. Chlorhexidine for Prophylaxis Against Oral Infections and Associated Complications in Patients Receiving Bone Marrow Transplants. J Am Dent Assoc. 1987;114(4):461-7. PubMed PMID: 3549834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chlorhexidine for prophylaxis against oral infections and associated complications in patients receiving bone marrow transplants. AU - Ferretti,G A, AU - Ash,R C, AU - Brown,A T, AU - Largent,B M, AU - Kaplan,A, AU - Lillich,T T, PY - 1987/4/1/pubmed PY - 1987/4/1/medline PY - 1987/4/1/entrez SP - 461 EP - 7 JF - Journal of the American Dental Association (1939) JO - J Am Dent Assoc VL - 114 IS - 4 N2 - Intensive chemoradiotherapy damages the mucosal barrier of the mouth and throat and is often associated with severe oral inflammation and infection. This study examined the use of a 0.12% chlorhexidine gluconate mouthrinse for prophylaxis against oral complications in patients receiving bone marrow transplants. Use of chlorhexidine mouthrinse produced reductions in oral soft tissue disease and oral microbial burden, including a significant decrease in oral mucositis and Candida infections. The advantage for patients undergoing intensive antineoplastic therapy, and potentially for other immunocompromised patients susceptible to oral infections, was studied. SN - 0002-8177 UR - https://www.unboundmedicine.com/medline/citation/3549834/Chlorhexidine_for_prophylaxis_against_oral_infections_and_associated_complications_in_patients_receiving_bone_marrow_transplants_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-8177(87)44022-1 DB - PRIME DP - Unbound Medicine ER -