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Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation.
Am J Transplant. 2022 10; 22(10):2433-2442.AJ

Abstract

Racial/ethnic disparities persist in patients' access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates' receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinical trial of waitlisted candidates (January 1, 2014-December 31, 2019), we evaluated Hispanic and Non-Hispanic White (NHW) KT candidates' number of PLDs. Multivariable logistic regression assessed the impact of PLDs on transplantation (KT vs. no KT; for KT recipients, LDKT vs. deceased donor KT). A total of 847 candidates were included, identifying as Hispanic (45.8%) or NHW (54.2%). For Site A, both Hispanic (adjusted OR = 2.26 [95% CI 1.13-4.53]) and NHW (OR = 2.42 [1.10-5.33]) candidates with PLDs completing the questionnaire were more likely to receive a KT. For Site B, candidates with PLDs were not significantly more likely to receive KT. Among KT recipients at both sites, Hispanic (Site A: OR = 21.22 [2.44-184.88]; Site B: OR = 25.54 [7.52-101.54]), and NHW (Site A: OR = 37.70 [6.59-215.67]; Site B: OR = 15.18 [5.64-40.85]) recipients with PLD(s) were significantly more likely to receive a LDKT. Our findings suggest that PLDs increased candidates' likelihood of KT receipt, particularly LDKT. Transplant programs should help candidates identify PLDs early in transplant evaluation.

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Authors+Show Affiliations

Gordon EJ
Department of Surgery- Division of Transplantation, Center for Health Services and Outcomes Research, Center for Bioethics and Medical Humanities, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Lee J
Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kang R
Center for Community Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Caicedo JC
Department of Surgery- Division of Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

MeSH

Clinical Trials as TopicEthnicityHumansKidney Failure, ChronicKidney TransplantationLiving DonorsRacial Groups

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

35524363

Clinical Trial Links

Clinical trial which this article describes

Citation

Gordon, Elisa J., et al. "Impact of Having Potential Living Donors On Ethnic/racial Disparities in Access to Kidney Transplantation." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 22, no. 10, 2022, pp. 2433-2442.
Gordon EJ, Lee J, Kang R, et al. Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation. Am J Transplant. 2022;22(10):2433-2442.
Gordon, E. J., Lee, J., Kang, R., & Caicedo, J. C. (2022). Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 22(10), 2433-2442. https://doi.org/10.1111/ajt.17090
Gordon EJ, et al. Impact of Having Potential Living Donors On Ethnic/racial Disparities in Access to Kidney Transplantation. Am J Transplant. 2022;22(10):2433-2442. PubMed PMID: 35524363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of having potential living donors on ethnic/racial disparities in access to kidney transplantation. AU - Gordon,Elisa J, AU - Lee,Jungwha, AU - Kang,Raymond, AU - Caicedo,Juan Carlos, Y1 - 2022/05/24/ PY - 2022/04/10/revised PY - 2022/02/10/received PY - 2022/05/03/accepted PY - 2022/5/8/pubmed PY - 2022/10/7/medline PY - 2022/5/7/entrez KW - Latinx KW - health disparities KW - kidney failure SP - 2433 EP - 2442 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am J Transplant VL - 22 IS - 10 N2 - Racial/ethnic disparities persist in patients' access to living donor kidney transplantation (LDKT). This study assessed the impact of having available potential living donors (PLDs) on candidates' receipt of a kidney transplant (KT) and LDKT at two KT programs. Using data from our clinical trial of waitlisted candidates (January 1, 2014-December 31, 2019), we evaluated Hispanic and Non-Hispanic White (NHW) KT candidates' number of PLDs. Multivariable logistic regression assessed the impact of PLDs on transplantation (KT vs. no KT; for KT recipients, LDKT vs. deceased donor KT). A total of 847 candidates were included, identifying as Hispanic (45.8%) or NHW (54.2%). For Site A, both Hispanic (adjusted OR = 2.26 [95% CI 1.13-4.53]) and NHW (OR = 2.42 [1.10-5.33]) candidates with PLDs completing the questionnaire were more likely to receive a KT. For Site B, candidates with PLDs were not significantly more likely to receive KT. Among KT recipients at both sites, Hispanic (Site A: OR = 21.22 [2.44-184.88]; Site B: OR = 25.54 [7.52-101.54]), and NHW (Site A: OR = 37.70 [6.59-215.67]; Site B: OR = 15.18 [5.64-40.85]) recipients with PLD(s) were significantly more likely to receive a LDKT. Our findings suggest that PLDs increased candidates' likelihood of KT receipt, particularly LDKT. Transplant programs should help candidates identify PLDs early in transplant evaluation. SN - 1600-6143 UR - https://www.unboundmedicine.com/medline/citation/35524363/Impact_of_having_potential_living_donors_on_ethnic/racial_disparities_in_access_to_kidney_transplantation_ DB - PRIME DP - Unbound Medicine ER -