Abstract
OBJECTIVE
This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women.
METHODS
This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes.
RESULTS
The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = -0.06) and correlated with age (r = 0.17), GFR (r = -0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = -0.08 [95% CI: -0.21; 0.06]) and were associated with age (OR = -0.23 [95% CI: -0.29; -0.17]), adiposity (OR = -6.52 [95% CI: -9.53; -3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]).
CONCLUSIONS
HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.
TY - JOUR
T1 - Plasma homocysteine levels and handgrip strength in postmenopausal women.
AU - García-Alfaro,P,
AU - Rodriguez,I,
AU - Pérez-López,F R,
Y1 - 2022/05/09/
PY - 2022/5/10/pubmed
PY - 2022/5/10/medline
PY - 2022/5/9/entrez
KW - Body mass index
KW - creatinine
KW - glomerular filtration rate
KW - handgrip strength
KW - homocysteine
KW - hyperhomocysteinemia
KW - mean corpuscular volume
SP - 1
EP - 6
JF - Climacteric : the journal of the International Menopause Society
JO - Climacteric
N2 - OBJECTIVE: This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women. METHODS: This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes. RESULTS: The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = -0.06) and correlated with age (r = 0.17), GFR (r = -0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = -0.08 [95% CI: -0.21; 0.06]) and were associated with age (OR = -0.23 [95% CI: -0.29; -0.17]), adiposity (OR = -6.52 [95% CI: -9.53; -3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]). CONCLUSIONS: HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.
SN - 1473-0804
UR - https://www.unboundmedicine.com/medline/citation/35532029/Plasma_homocysteine_levels_and_handgrip_strength_in_postmenopausal_women.
L2 - https://www.tandfonline.com/doi/full/10.1080/13697137.2022.2068409
DB - PRIME
DP - Unbound Medicine
ER -
