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Plasma homocysteine levels and handgrip strength in postmenopausal women.
Climacteric. 2022 May 09 [Online ahead of print]C

Abstract

OBJECTIVE

This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women.

METHODS

This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes.

RESULTS

The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = -0.06) and correlated with age (r = 0.17), GFR (r = -0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = -0.08 [95% CI: -0.21; 0.06]) and were associated with age (OR = -0.23 [95% CI: -0.29; -0.17]), adiposity (OR = -6.52 [95% CI: -9.53; -3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]).

CONCLUSIONS

HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels.

Authors+Show Affiliations

Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Dexeus, Barcelona, Spain.Department of Obstetrics, Gynecology and Reproduction, Hospital Universitario Dexeus, Barcelona, Spain.Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine, Zaragoza, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35532029

Citation

García-Alfaro, P, et al. "Plasma Homocysteine Levels and Handgrip Strength in Postmenopausal Women." Climacteric : the Journal of the International Menopause Society, 2022, pp. 1-6.
García-Alfaro P, Rodriguez I, Pérez-López FR. Plasma homocysteine levels and handgrip strength in postmenopausal women. Climacteric. 2022.
García-Alfaro, P., Rodriguez, I., & Pérez-López, F. R. (2022). Plasma homocysteine levels and handgrip strength in postmenopausal women. Climacteric : the Journal of the International Menopause Society, 1-6. https://doi.org/10.1080/13697137.2022.2068409
García-Alfaro P, Rodriguez I, Pérez-López FR. Plasma Homocysteine Levels and Handgrip Strength in Postmenopausal Women. Climacteric. 2022 May 9;1-6. PubMed PMID: 35532029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma homocysteine levels and handgrip strength in postmenopausal women. AU - García-Alfaro,P, AU - Rodriguez,I, AU - Pérez-López,F R, Y1 - 2022/05/09/ PY - 2022/5/10/pubmed PY - 2022/5/10/medline PY - 2022/5/9/entrez KW - Body mass index KW - creatinine KW - glomerular filtration rate KW - handgrip strength KW - homocysteine KW - hyperhomocysteinemia KW - mean corpuscular volume SP - 1 EP - 6 JF - Climacteric : the journal of the International Menopause Society JO - Climacteric N2 - OBJECTIVE: This study evaluated handgrip strength (HGS), circulating homocysteine levels and related factors in postmenopausal women. METHODS: This study is a sub-analysis of a prospective cohort of 303 postmenopausal women aged 62.7 ± 6.9 years who had HGS measures with a digital dynamometer as the primary outcome, and plasma homocysteine and creatinine levels and glomerular filtration rate (GFR) measures as the secondary outcomes. RESULTS: The average HGS was 22.5 ± 4.0 kg, 29.4% of women had dynapenia (HGS < 20 kg), adiposity was 40.3 ± 5.4% and 9.57% of women had hyperhomocysteinemia (homocysteine >15 μmol/l). There were no differences between tertiles of homocysteine and HGS (p = 0.641). Plasma homocysteine levels were unrelated to HGS (r = -0.06) and correlated with age (r = 0.17), GFR (r = -0.28) and creatinine (r = 0.23). Hyperhomocysteinemia was not associated with HGS (odds ratio [OR] = 0.98 [95% confidence interval (CI): 0.89; 1.08]) or dynapenia (OR = 1.10 [95% CI: 0.45; 2.47]). The risk of presenting low HGS were not significantly associated with homocysteine (OR = -0.08 [95% CI: -0.21; 0.06]) and were associated with age (OR = -0.23 [95% CI: -0.29; -0.17]), adiposity (OR = -6.52 [95% CI: -9.53; -3.50]) and creatinine (OR = 6.22 [95% CI: 2.48; 9.97]). CONCLUSIONS: HGS and dynapenia were unrelated to hyperhomocysteinemia. Age, GFR and creatinine were significantly associated with plasma homocysteine levels. SN - 1473-0804 UR - https://www.unboundmedicine.com/medline/citation/35532029/Plasma_homocysteine_levels_and_handgrip_strength_in_postmenopausal_women. L2 - https://www.tandfonline.com/doi/full/10.1080/13697137.2022.2068409 DB - PRIME DP - Unbound Medicine ER -
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