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The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man.
J Allergy Clin Immunol. 1987 May; 79(5):816-21.JA

Abstract

We have studied the effect of prior treatment with an oral leukotriene (LT) antagonist L-649,923, on histamine and LTD4-induced bronchoconstriction in 12 normal male subjects in a double-blind, placebo-controlled, randomized, crossover trial. L-649,923 had no effect on histamine-induced bronchoconstriction but antagonized LTD4-induced bronchoconstriction, causing a mean shift to the right of the dose-response curves of 3.8-fold. This study demonstrates that LT antagonism is possible and safe in man and that LTD4-inhalation challenge testing can be used to detect LT antagonism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3553279

Citation

Barnes, N, et al. "The Effect of an Oral Leukotriene Antagonist L-649,923 On Histamine and Leukotriene D4-induced Bronchoconstriction in Normal Man." The Journal of Allergy and Clinical Immunology, vol. 79, no. 5, 1987, pp. 816-21.
Barnes N, Piper PJ, Costello J. The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man. J Allergy Clin Immunol. 1987;79(5):816-21.
Barnes, N., Piper, P. J., & Costello, J. (1987). The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man. The Journal of Allergy and Clinical Immunology, 79(5), 816-21.
Barnes N, Piper PJ, Costello J. The Effect of an Oral Leukotriene Antagonist L-649,923 On Histamine and Leukotriene D4-induced Bronchoconstriction in Normal Man. J Allergy Clin Immunol. 1987;79(5):816-21. PubMed PMID: 3553279.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of an oral leukotriene antagonist L-649,923 on histamine and leukotriene D4-induced bronchoconstriction in normal man. AU - Barnes,N, AU - Piper,P J, AU - Costello,J, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 816 EP - 21 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 79 IS - 5 N2 - We have studied the effect of prior treatment with an oral leukotriene (LT) antagonist L-649,923, on histamine and LTD4-induced bronchoconstriction in 12 normal male subjects in a double-blind, placebo-controlled, randomized, crossover trial. L-649,923 had no effect on histamine-induced bronchoconstriction but antagonized LTD4-induced bronchoconstriction, causing a mean shift to the right of the dose-response curves of 3.8-fold. This study demonstrates that LT antagonism is possible and safe in man and that LTD4-inhalation challenge testing can be used to detect LT antagonism. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/3553279/The_effect_of_an_oral_leukotriene_antagonist_L_649923_on_histamine_and_leukotriene_D4_induced_bronchoconstriction_in_normal_man_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-6749(87)90215-6 DB - PRIME DP - Unbound Medicine ER -