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[Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone].
Z Hautkr. 1987 Jan 01; 62(1):28-38.ZH

Abstract

In a randomized double blind study, 50 patients suffering from trunk or branch varicosis were orally treated with either a commercial preparation of Ruscus extract, trimethyl hesperidine chalcone and ascorbic acid (Phlebodril), or a placebo over 2 weeks. Changes of the venous tonus were measured by means of venous occlusion plethysmography in rest position (venous capacity, venous distensibility) as well as during (active) exercise (expelled blood volume). All parameters showed a tendency towards improvement in the verum group. The changes were partly significant (p less than 0.5). The course of the study suggests that the period of treatment possibly was too short to obtain the full pharmacologic effect.

Authors

Weindorf N
No affiliation info available
Schultz-Ehrenburg U
No affiliation info available

MeSH

Administration, OralAdultAgedChalconeClinical Trials as TopicDouble-Blind MethodDrug CombinationsFemaleFlavonoidsHesperidinHumansMaleMiddle AgedPlant ExtractsPlethysmographyPropiophenonesRandom AllocationRheologyVaricose VeinsVascular ResistanceVenous Insufficiency

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

3554800

Citation

Weindorf, N, and U Schultz-Ehrenburg. "[Controlled Study of Increasing Venous Tone in Primary Varicose Veins By Oral Administration of Ruscus Aculeatus and Trimethylhespiridinchalcone]." Zeitschrift Fur Hautkrankheiten, vol. 62, no. 1, 1987, pp. 28-38.
Weindorf N, Schultz-Ehrenburg U. [Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone]. Z Hautkr. 1987;62(1):28-38.
Weindorf, N., & Schultz-Ehrenburg, U. (1987). [Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone]. Zeitschrift Fur Hautkrankheiten, 62(1), 28-38.
Weindorf N, Schultz-Ehrenburg U. [Controlled Study of Increasing Venous Tone in Primary Varicose Veins By Oral Administration of Ruscus Aculeatus and Trimethylhespiridinchalcone]. Z Hautkr. 1987 Jan 1;62(1):28-38. PubMed PMID: 3554800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Controlled study of increasing venous tone in primary varicose veins by oral administration of Ruscus aculeatus and trimethylhespiridinchalcone]. AU - Weindorf,N, AU - Schultz-Ehrenburg,U, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 28 EP - 38 JF - Zeitschrift fur Hautkrankheiten JO - Z Hautkr VL - 62 IS - 1 N2 - In a randomized double blind study, 50 patients suffering from trunk or branch varicosis were orally treated with either a commercial preparation of Ruscus extract, trimethyl hesperidine chalcone and ascorbic acid (Phlebodril), or a placebo over 2 weeks. Changes of the venous tonus were measured by means of venous occlusion plethysmography in rest position (venous capacity, venous distensibility) as well as during (active) exercise (expelled blood volume). All parameters showed a tendency towards improvement in the verum group. The changes were partly significant (p less than 0.5). The course of the study suggests that the period of treatment possibly was too short to obtain the full pharmacologic effect. SN - 0301-0481 UR - https://www.unboundmedicine.com/medline/citation/3554800/[Controlled_study_of_increasing_venous_tone_in_primary_varicose_veins_by_oral_administration_of_Ruscus_aculeatus_and_trimethylhespiridinchalcone]_ L2 - https://medlineplus.gov/varicoseveins.html DB - PRIME DP - Unbound Medicine ER -