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Dermal pericapillary fibrin in venous disease and venous ulceration.
Arch Dermatol. 1987 May; 123(5):620-3.AD

Abstract

Pericapillary fibrin deposition is thought to contribute to the pathogenesis of venous ulceration. To our knowledge, however, there is no previous evidence that pericapillary fibrin is deposited in the tissue adjacent to venous ulcers. We prospectively studied patients with ulcers of the lower extremities for the presence of dermal pericapillary fibrin in the skin adjacent tot he ulcers. On direct immunofluorescence, pericapillary fibrin was found in 14 (93%) of the 15 patients with venous ulceration but in only one (7%) of the 14 subjects with ulcers due to other causes. We also confirmed the presence of dermal pericapillary fibrin in legs with venous disease without ulcerations. We conclude that the pericapillary fibrin is easily demonstrable in the dermis adjacent to venous ulcers. In the evaluation of ulcers due to uncertain causes, the presence of dermal pericapillary fibrin may provide additional diagnostic help.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3555351

Citation

Falanga, V, et al. "Dermal Pericapillary Fibrin in Venous Disease and Venous Ulceration." Archives of Dermatology, vol. 123, no. 5, 1987, pp. 620-3.
Falanga V, Moosa HH, Nemeth AJ, et al. Dermal pericapillary fibrin in venous disease and venous ulceration. Arch Dermatol. 1987;123(5):620-3.
Falanga, V., Moosa, H. H., Nemeth, A. J., Alstadt, S. P., & Eaglstein, W. H. (1987). Dermal pericapillary fibrin in venous disease and venous ulceration. Archives of Dermatology, 123(5), 620-3.
Falanga V, et al. Dermal Pericapillary Fibrin in Venous Disease and Venous Ulceration. Arch Dermatol. 1987;123(5):620-3. PubMed PMID: 3555351.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dermal pericapillary fibrin in venous disease and venous ulceration. AU - Falanga,V, AU - Moosa,H H, AU - Nemeth,A J, AU - Alstadt,S P, AU - Eaglstein,W H, PY - 1987/5/1/pubmed PY - 1987/5/1/medline PY - 1987/5/1/entrez SP - 620 EP - 3 JF - Archives of dermatology JO - Arch Dermatol VL - 123 IS - 5 N2 - Pericapillary fibrin deposition is thought to contribute to the pathogenesis of venous ulceration. To our knowledge, however, there is no previous evidence that pericapillary fibrin is deposited in the tissue adjacent to venous ulcers. We prospectively studied patients with ulcers of the lower extremities for the presence of dermal pericapillary fibrin in the skin adjacent tot he ulcers. On direct immunofluorescence, pericapillary fibrin was found in 14 (93%) of the 15 patients with venous ulceration but in only one (7%) of the 14 subjects with ulcers due to other causes. We also confirmed the presence of dermal pericapillary fibrin in legs with venous disease without ulcerations. We conclude that the pericapillary fibrin is easily demonstrable in the dermis adjacent to venous ulcers. In the evaluation of ulcers due to uncertain causes, the presence of dermal pericapillary fibrin may provide additional diagnostic help. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/3555351/Dermal_pericapillary_fibrin_in_venous_disease_and_venous_ulceration_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/123/pg/620 DB - PRIME DP - Unbound Medicine ER -