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Sulfite hypersensitivity. A critical review.
CRC Crit Rev Toxicol 1987; 17(3):185-214CC

Abstract

Sulfiting agents (sulfur dioxide and the sodium and potassium salts of bisulfite, sulfite, and metabisulfite) are widely used as preservatives in foods, beverages, and pharmaceuticals. Within the past 5 years, there have been numerous reports of adverse reactions to sulfiting agents. This review presents a comprehensive compilation and discussion of reports describing reactions to ingested, inhaled, and parenterally administered sulfite. Sulfite hypersensitivity is usually, but not exclusively, found within the chronic asthmatic population. Although there is some disagreement on its prevalence, a number of studies have indicated that 5 to 10% of all chronic asthmatics are sulfite hypersensitive. This review also describes respiratory sulfur dioxide sensitivity which essentially all asthmatics experience. Possible mechanisms of sulfite hypersensitivity and sulfur dioxide sensitivity are discussed in detail. Sulfite metabolism and the role of sulfite oxidase in the detoxification of exogenous sulfite are reviewed in relationship to the etiology of sulfite hypersensitivity.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

3556020

Citation

Gunnison, A F., and D W. Jacobsen. "Sulfite Hypersensitivity. a Critical Review." CRC Critical Reviews in Toxicology, vol. 17, no. 3, 1987, pp. 185-214.
Gunnison AF, Jacobsen DW. Sulfite hypersensitivity. A critical review. CRC Crit Rev Toxicol. 1987;17(3):185-214.
Gunnison, A. F., & Jacobsen, D. W. (1987). Sulfite hypersensitivity. A critical review. CRC Critical Reviews in Toxicology, 17(3), pp. 185-214.
Gunnison AF, Jacobsen DW. Sulfite Hypersensitivity. a Critical Review. CRC Crit Rev Toxicol. 1987;17(3):185-214. PubMed PMID: 3556020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sulfite hypersensitivity. A critical review. AU - Gunnison,A F, AU - Jacobsen,D W, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 185 EP - 214 JF - CRC critical reviews in toxicology JO - CRC Crit Rev Toxicol VL - 17 IS - 3 N2 - Sulfiting agents (sulfur dioxide and the sodium and potassium salts of bisulfite, sulfite, and metabisulfite) are widely used as preservatives in foods, beverages, and pharmaceuticals. Within the past 5 years, there have been numerous reports of adverse reactions to sulfiting agents. This review presents a comprehensive compilation and discussion of reports describing reactions to ingested, inhaled, and parenterally administered sulfite. Sulfite hypersensitivity is usually, but not exclusively, found within the chronic asthmatic population. Although there is some disagreement on its prevalence, a number of studies have indicated that 5 to 10% of all chronic asthmatics are sulfite hypersensitive. This review also describes respiratory sulfur dioxide sensitivity which essentially all asthmatics experience. Possible mechanisms of sulfite hypersensitivity and sulfur dioxide sensitivity are discussed in detail. Sulfite metabolism and the role of sulfite oxidase in the detoxification of exogenous sulfite are reviewed in relationship to the etiology of sulfite hypersensitivity. SN - 0045-6446 UR - https://www.unboundmedicine.com/medline/citation/3556020/Sulfite_hypersensitivity__A_critical_review_ L2 - https://medlineplus.gov/foodallergy.html DB - PRIME DP - Unbound Medicine ER -