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MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases.
Int J Mol Sci. 2022 Apr 25; 23(9)IJ

Abstract

MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions and play a key role in pathological conditions. Numerous studies have demonstrated that miRNAs are dysregulated in major neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, or Huntington's disease. Hence, in the present work, we constructed a comprehensive overview of individual microRNA alterations in various models of the above neurodegenerative diseases. We also provided evidence of miRNAs as promising biomarkers for prognostic and diagnostic approaches. In addition, we summarized data from the literature about miRNA-based therapeutic applications via inhibiting or promoting miRNA expression. We finally identified the overlapping miRNA signature across the diseases, including miR-128, miR-140-5p, miR-206, miR-326, and miR-155, associated with multiple etiological cellular mechanisms. However, it remains to be established whether and to what extent miRNA-based therapies could be safely exploited in the future as effective symptomatic or disease-modifying approaches in the different human neurodegenerative disorders.

Authors+Show Affiliations

Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy.Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy. IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy. IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.Pharmacology and Toxicology Unit, Department of Pharmacy, University of Genoa, Viale Cembrano 4, 16148 Genoa, Italy. Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research (Centro 3R), 56122 Genoa, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35563107

Citation

Nguyen, T P Nhung, et al. "MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 23, no. 9, 2022.
Nguyen TPN, Kumar M, Fedele E, et al. MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases. Int J Mol Sci. 2022;23(9).
Nguyen, T. P. N., Kumar, M., Fedele, E., Bonanno, G., & Bonifacino, T. (2022). MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases. International Journal of Molecular Sciences, 23(9). https://doi.org/10.3390/ijms23094718
Nguyen TPN, et al. MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases. Int J Mol Sci. 2022 Apr 25;23(9) PubMed PMID: 35563107.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNA Alteration, Application as Biomarkers, and Therapeutic Approaches in Neurodegenerative Diseases. AU - Nguyen,T P Nhung, AU - Kumar,Mandeep, AU - Fedele,Ernesto, AU - Bonanno,Giambattista, AU - Bonifacino,Tiziana, Y1 - 2022/04/25/ PY - 2022/3/31/received PY - 2022/4/20/revised PY - 2022/4/21/accepted PY - 2022/5/14/entrez PY - 2022/5/15/pubmed PY - 2022/5/18/medline KW - Alzheimer’s disease (AD) KW - Huntington’s disease (HD) KW - Parkinson’s disease (PD) KW - amyotrophic lateral sclerosis (ALS) KW - biomarker KW - dysregulation KW - microRNAs (miRNAs) KW - multiple sclerosis (MS) KW - neurodegenerative diseases JF - International journal of molecular sciences JO - Int J Mol Sci VL - 23 IS - 9 N2 - MicroRNAs (miRNAs) are essential post-transcriptional gene regulators involved in various neuronal and non-neuronal cell functions and play a key role in pathological conditions. Numerous studies have demonstrated that miRNAs are dysregulated in major neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, or Huntington's disease. Hence, in the present work, we constructed a comprehensive overview of individual microRNA alterations in various models of the above neurodegenerative diseases. We also provided evidence of miRNAs as promising biomarkers for prognostic and diagnostic approaches. In addition, we summarized data from the literature about miRNA-based therapeutic applications via inhibiting or promoting miRNA expression. We finally identified the overlapping miRNA signature across the diseases, including miR-128, miR-140-5p, miR-206, miR-326, and miR-155, associated with multiple etiological cellular mechanisms. However, it remains to be established whether and to what extent miRNA-based therapies could be safely exploited in the future as effective symptomatic or disease-modifying approaches in the different human neurodegenerative disorders. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/35563107/MicroRNA_Alteration_Application_as_Biomarkers_and_Therapeutic_Approaches_in_Neurodegenerative_Diseases_ DB - PRIME DP - Unbound Medicine ER -