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Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats by Modulation of NF-κB and Nrf2/HO-1 Axes.
Nutrients. 2022 Apr 30; 14(9)N

Abstract

Endometrial hyperplasia (EH) is the most common risk factor for endometrial malignancy in females. The pathogenesis of EH has been directly linked to uterine inflammation, which can result in abnormal cell division and decreased apoptosis. Piceatannol (PIC), a natural polyphenolic stilbene, is known to exert anti-inflammatory, antioxidant and anti-proliferative activities. The aim of the present study was to examine the potential preventive role of PIC in estradiol benzoate (EB)-induced EH in rats. A self-nanoemulsifying drug delivery system (SNEDDS) was prepared to improve the solubility of the PIC. Therefore, thirty female Wistar rats were divided into five groups: (1) control, (2) PIC SNEDDS (10 mg/kg), (3) EB (0.6 mg/kg), (4) EB + PIC SNEDDS (5 mg/kg) and (5) EB + PIC SNEDDS (10 mg/kg). The administration of PIC SNEDDS prevented EB-induced increases in uterine weights and histopathological changes. Additionally, it displayed pro-apoptotic and antioxidant activity in the endometrium. Immunohistochemical staining of uterine sections co-treated with PIC SNEDDS showed significantly decreased expression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nuclear transcription factor-kappa B (NF-κB). This anti-inflammatory effect was further confirmed by a significant increase in Nrf2 and heme oxygenase-1 (HO-1) expression. These results indicate that SNEDDS nanoformulation of PIC possesses protective effects against experimentally induced EH.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.Department of Anatomical Histopathology, East Jeddah General Hospital, Jeddah 22253, Saudi Arabia.Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35565857

Citation

Binmahfouz, Lenah S., et al. "Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats By Modulation of NF-κB and Nrf2/HO-1 Axes." Nutrients, vol. 14, no. 9, 2022.
Binmahfouz LS, Eid BG, Bagher AM, et al. Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats by Modulation of NF-κB and Nrf2/HO-1 Axes. Nutrients. 2022;14(9).
Binmahfouz, L. S., Eid, B. G., Bagher, A. M., Shaik, R. A., Binmahfouz, N. S., & Abdel-Naim, A. B. (2022). Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats by Modulation of NF-κB and Nrf2/HO-1 Axes. Nutrients, 14(9). https://doi.org/10.3390/nu14091891
Binmahfouz LS, et al. Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats By Modulation of NF-κB and Nrf2/HO-1 Axes. Nutrients. 2022 Apr 30;14(9) PubMed PMID: 35565857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Piceatannol SNEDDS Attenuates Estradiol-Induced Endometrial Hyperplasia in Rats by Modulation of NF-κB and Nrf2/HO-1 Axes. AU - Binmahfouz,Lenah S, AU - Eid,Basma G, AU - Bagher,Amina M, AU - Shaik,Rasheed A, AU - Binmahfouz,Najlaa S, AU - Abdel-Naim,Ashraf B, Y1 - 2022/04/30/ PY - 2022/04/10/received PY - 2022/04/26/revised PY - 2022/04/28/accepted PY - 2022/5/14/entrez PY - 2022/5/15/pubmed PY - 2022/5/18/medline KW - endometrial hyperplasia KW - estradiol benzoate KW - inflammation KW - oxidative stress KW - piceatannol JF - Nutrients JO - Nutrients VL - 14 IS - 9 N2 - Endometrial hyperplasia (EH) is the most common risk factor for endometrial malignancy in females. The pathogenesis of EH has been directly linked to uterine inflammation, which can result in abnormal cell division and decreased apoptosis. Piceatannol (PIC), a natural polyphenolic stilbene, is known to exert anti-inflammatory, antioxidant and anti-proliferative activities. The aim of the present study was to examine the potential preventive role of PIC in estradiol benzoate (EB)-induced EH in rats. A self-nanoemulsifying drug delivery system (SNEDDS) was prepared to improve the solubility of the PIC. Therefore, thirty female Wistar rats were divided into five groups: (1) control, (2) PIC SNEDDS (10 mg/kg), (3) EB (0.6 mg/kg), (4) EB + PIC SNEDDS (5 mg/kg) and (5) EB + PIC SNEDDS (10 mg/kg). The administration of PIC SNEDDS prevented EB-induced increases in uterine weights and histopathological changes. Additionally, it displayed pro-apoptotic and antioxidant activity in the endometrium. Immunohistochemical staining of uterine sections co-treated with PIC SNEDDS showed significantly decreased expression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nuclear transcription factor-kappa B (NF-κB). This anti-inflammatory effect was further confirmed by a significant increase in Nrf2 and heme oxygenase-1 (HO-1) expression. These results indicate that SNEDDS nanoformulation of PIC possesses protective effects against experimentally induced EH. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/35565857/Piceatannol_SNEDDS_Attenuates_Estradiol_Induced_Endometrial_Hyperplasia_in_Rats_by_Modulation_of_NF_κB_and_Nrf2/HO_1_Axes_ L2 - https://www.mdpi.com/resolver?pii=nu14091891 DB - PRIME DP - Unbound Medicine ER -