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Effect of simultaneous administration of live measles vaccine on the "take rate" of live mumps vaccine.
Dev Biol Stand. 1986; 65:101-7.DB

Abstract

During the course of clinical studies to develop a new bivalent measles-mumps vaccine, it was established that simultaneous administration of live measles and mumps vaccines at doses contained in the monovalent vaccines resulted in a reduced seroconversion rate against mumps but not against measles. This one-way interference was resolved by increasing the dose of the mumps component in the bivalent measles-mumps and the trivalent measles-mumps-rubella vaccines above that in the monovalent mumps vaccine. On the other hand, it was not necessary to adjust the doses of the measles and rubella components in the combined vaccines. This observation requires that not only the titres of vaccine viruses must be carefully adjusted in combined live mumps vaccines but also that the heat-stability of each component in such vaccines be carefully determined to ensure that interference is not a problem during the complete shelf-life of the product. The relative doses at release of combined mumps vaccines using the Urabe Am 9 strain and the heat-stability characteristics of these products will be presented and discussed.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3556770

Citation

André, F E., and J Peetermans. "Effect of Simultaneous Administration of Live Measles Vaccine On the "take Rate" of Live Mumps Vaccine." Developments in Biological Standardization, vol. 65, 1986, pp. 101-7.
André FE, Peetermans J. Effect of simultaneous administration of live measles vaccine on the "take rate" of live mumps vaccine. Dev Biol Stand. 1986;65:101-7.
André, F. E., & Peetermans, J. (1986). Effect of simultaneous administration of live measles vaccine on the "take rate" of live mumps vaccine. Developments in Biological Standardization, 65, 101-7.
André FE, Peetermans J. Effect of Simultaneous Administration of Live Measles Vaccine On the "take Rate" of Live Mumps Vaccine. Dev Biol Stand. 1986;65:101-7. PubMed PMID: 3556770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of simultaneous administration of live measles vaccine on the "take rate" of live mumps vaccine. AU - André,F E, AU - Peetermans,J, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - 101 EP - 7 JF - Developments in biological standardization JO - Dev Biol Stand VL - 65 N2 - During the course of clinical studies to develop a new bivalent measles-mumps vaccine, it was established that simultaneous administration of live measles and mumps vaccines at doses contained in the monovalent vaccines resulted in a reduced seroconversion rate against mumps but not against measles. This one-way interference was resolved by increasing the dose of the mumps component in the bivalent measles-mumps and the trivalent measles-mumps-rubella vaccines above that in the monovalent mumps vaccine. On the other hand, it was not necessary to adjust the doses of the measles and rubella components in the combined vaccines. This observation requires that not only the titres of vaccine viruses must be carefully adjusted in combined live mumps vaccines but also that the heat-stability of each component in such vaccines be carefully determined to ensure that interference is not a problem during the complete shelf-life of the product. The relative doses at release of combined mumps vaccines using the Urabe Am 9 strain and the heat-stability characteristics of these products will be presented and discussed. SN - 0301-5149 UR - https://www.unboundmedicine.com/medline/citation/3556770/Effect_of_simultaneous_administration_of_live_measles_vaccine_on_the_"take_rate"_of_live_mumps_vaccine_ L2 - https://www.diseaseinfosearch.org/result/4977 DB - PRIME DP - Unbound Medicine ER -