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Determining Susceptibility in Candida Vaginal Isolates.
Antimicrob Agents Chemother. 2022 06 21; 66(6):e0236621.AA

Abstract

Antifungal drug susceptibility tests (AST) for Candida albicans are increasingly demanded for women with refractory or recurrent Candida vaginitis due to fluconazole resistance. Given reduced activity of azole drugs at pH levels found in women with Candida vaginitis, it is proposed that AST be performed at pH 4.5, since testing at only the recommended pH 7.0 is likely to miss a significant number of clinically relevant azole-resistant C. albicans vaginal isolates.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Sobel JD
Department of Internal Medicine, Wayne State Universitygrid.254444.7, Detroit, Michigan, USA.
Akins R
Department of Biochemistry, Microbiology, and Immunology, Wayne State Universitygrid.254444.7, Detroit, Michigan, USA.

MeSH

Antifungal AgentsAzolesCandidaCandida albicansCandidiasis, VulvovaginalDrug Resistance, FungalFemaleFluconazoleHumansMicrobial Sensitivity Tests

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35604210

Citation

Sobel, Jack D., and Robert Akins. "Determining Susceptibility in Candida Vaginal Isolates." Antimicrobial Agents and Chemotherapy, vol. 66, no. 6, 2022, pp. e0236621.
Sobel JD, Akins R. Determining Susceptibility in Candida Vaginal Isolates. Antimicrob Agents Chemother. 2022;66(6):e0236621.
Sobel, J. D., & Akins, R. (2022). Determining Susceptibility in Candida Vaginal Isolates. Antimicrobial Agents and Chemotherapy, 66(6), e0236621. https://doi.org/10.1128/aac.02366-21
Sobel JD, Akins R. Determining Susceptibility in Candida Vaginal Isolates. Antimicrob Agents Chemother. 2022 06 21;66(6):e0236621. PubMed PMID: 35604210.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determining Susceptibility in Candida Vaginal Isolates. AU - Sobel,Jack D, AU - Akins,Robert, Y1 - 2022/05/23/ PY - 2022/11/23/pmc-release PY - 2022/5/24/pubmed PY - 2022/6/24/medline PY - 2022/5/23/entrez KW - Candida albicans KW - antifungal drug resistance KW - antifungal susceptibility tests KW - fluconazole KW - pH KW - susceptibility tests SP - e0236621 EP - e0236621 JF - Antimicrobial agents and chemotherapy JO - Antimicrob Agents Chemother VL - 66 IS - 6 N2 - Antifungal drug susceptibility tests (AST) for Candida albicans are increasingly demanded for women with refractory or recurrent Candida vaginitis due to fluconazole resistance. Given reduced activity of azole drugs at pH levels found in women with Candida vaginitis, it is proposed that AST be performed at pH 4.5, since testing at only the recommended pH 7.0 is likely to miss a significant number of clinically relevant azole-resistant C. albicans vaginal isolates. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/35604210/Determining_Susceptibility_in_Candida_Vaginal_Isolates. DB - PRIME DP - Unbound Medicine ER -