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Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension.
Parkinsonism Relat Disord. 2022 Jun; 99:62-64.PR

Abstract

We evaluate the effect of droxidopa on gait and balance measures in nine patients with Parkinson's disease and neurogenic orthostatic hypotension. Computerized gait/balance analysis showed a significant effect of droxidopa in reducing postural sway. Future studies may determine if such effect translates into improvement in postural reflexes and falls.

Authors+Show Affiliations

James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: luca.marsili@uc.edu.James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: duqueykr@ucmail.uc.edu.James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA; Department of Clinical Neuroscience, Neuro Svenningsson, Karolinska Institute, 171 76, Stockholm, Sweden. Electronic address: andrea.sturchio@gmail.com.Autonomic and Orthostatic Hypotension Unit, Department of Medical Sciences; AOU Città della Salute e della Scienza di Torino, Turin, Italy. Electronic address: gabri.sobrero@gmail.com.Biomarker Department, Division of Experimental Medicine, H. Lundbeck A/S, 2500, Copenhagen, Denmark; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RX, UK. Electronic address: ISPR@lundbeck.com.Division of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center El Paso, Texas, USA. Electronic address: alok.dwivedi@ttuhsc.edu.James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: alberto.espay@uc.edu.Department of Neurology, Wexner Medical Center, Ohio State University, Columbus, OH, USA. Electronic address: aristidemerola@hotmail.com.

Pub Type(s)

Letter
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35605513

Citation

Marsili, Luca, et al. "Droxidopa Reduces Postural Sway in Parkinson Disease Patients With Orthostatic Hypotension." Parkinsonism & Related Disorders, vol. 99, 2022, pp. 62-64.
Marsili L, Duque KR, Sturchio A, et al. Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension. Parkinsonism Relat Disord. 2022;99:62-64.
Marsili, L., Duque, K. R., Sturchio, A., Sobrero, G., Premoli, I., Dwivedi, A. K., Espay, A. J., & Merola, A. (2022). Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension. Parkinsonism & Related Disorders, 99, 62-64. https://doi.org/10.1016/j.parkreldis.2022.05.002
Marsili L, et al. Droxidopa Reduces Postural Sway in Parkinson Disease Patients With Orthostatic Hypotension. Parkinsonism Relat Disord. 2022;99:62-64. PubMed PMID: 35605513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension. AU - Marsili,Luca, AU - Duque,Kevin R, AU - Sturchio,Andrea, AU - Sobrero,Gabriele, AU - Premoli,Isabella, AU - Dwivedi,Alok K, AU - Espay,Alberto J, AU - Merola,Aristide, Y1 - 2022/05/13/ PY - 2022/3/14/received PY - 2022/4/30/revised PY - 2022/5/8/accepted PY - 2022/5/24/pubmed PY - 2022/6/29/medline PY - 2022/5/23/entrez KW - Droxidopa KW - Orthostatic hypotension KW - Parkinson disease KW - Postural sway KW - Wearables SP - 62 EP - 64 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 99 N2 - We evaluate the effect of droxidopa on gait and balance measures in nine patients with Parkinson's disease and neurogenic orthostatic hypotension. Computerized gait/balance analysis showed a significant effect of droxidopa in reducing postural sway. Future studies may determine if such effect translates into improvement in postural reflexes and falls. SN - 1873-5126 UR - https://www.unboundmedicine.com/medline/citation/35605513/Droxidopa_reduces_postural_sway_in_Parkinson_disease_patients_with_orthostatic_hypotension_ DB - PRIME DP - Unbound Medicine ER -