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Emerging strategies for treating gout.
Curr Opin Pharmacol. 2022 08; 65:102241.CO

Abstract

Gout is a common and potentially debilitating disease characterized by a painful inflammatory arthritis ("gout flare"), caused by the deposition of monosodium urate crystals in joints and surrounding tissues. Gout is frequently comorbid with other chronic conditions such as chronic kidney disease (CKD) and diabetes mellitus, which can make treatment complex, as traditional mainstays (such as allopurinol, colchicine, and corticosteroids) may not be preferred or could have adverse events in such patients. Understanding the pathophysiology of hyperuricemia, gout, and crystalline-driven inflammation is key for drug development and research. Consequently, new agents and new protocols with existing agents are being proposed for safe and efficacious treatment in patients with a variety of comorbid conditions. This review will discuss such strategies that may be used in the future for gout treatment.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Huddleston EM
Tinsley Harrison Internal Medicine Residency Program, The University of Alabama at Birmingham (UAB), Birmingham, AL, USA.
Gaffo AL
Division of Clinical Immunology and Rheumatology, University of Alabama Birmingham (UAB) and Birmingham VA Medical Center, Birmingham, AL, USA. Electronic address: agaffo@uabmc.edu.

MeSH

ColchicineGoutGout SuppressantsHumansHyperuricemiaUric Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35609384

Citation

Huddleston, Edward M., and Angelo L. Gaffo. "Emerging Strategies for Treating Gout." Current Opinion in Pharmacology, vol. 65, 2022, p. 102241.
Huddleston EM, Gaffo AL. Emerging strategies for treating gout. Curr Opin Pharmacol. 2022;65:102241.
Huddleston, E. M., & Gaffo, A. L. (2022). Emerging strategies for treating gout. Current Opinion in Pharmacology, 65, 102241. https://doi.org/10.1016/j.coph.2022.102241
Huddleston EM, Gaffo AL. Emerging Strategies for Treating Gout. Curr Opin Pharmacol. 2022;65:102241. PubMed PMID: 35609384.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging strategies for treating gout. AU - Huddleston,Edward M, AU - Gaffo,Angelo L, Y1 - 2022/05/21/ PY - 2022/04/06/received PY - 2022/04/15/accepted PY - 2022/5/25/pubmed PY - 2022/7/27/medline PY - 2022/5/24/entrez SP - 102241 EP - 102241 JF - Current opinion in pharmacology JO - Curr Opin Pharmacol VL - 65 N2 - Gout is a common and potentially debilitating disease characterized by a painful inflammatory arthritis ("gout flare"), caused by the deposition of monosodium urate crystals in joints and surrounding tissues. Gout is frequently comorbid with other chronic conditions such as chronic kidney disease (CKD) and diabetes mellitus, which can make treatment complex, as traditional mainstays (such as allopurinol, colchicine, and corticosteroids) may not be preferred or could have adverse events in such patients. Understanding the pathophysiology of hyperuricemia, gout, and crystalline-driven inflammation is key for drug development and research. Consequently, new agents and new protocols with existing agents are being proposed for safe and efficacious treatment in patients with a variety of comorbid conditions. This review will discuss such strategies that may be used in the future for gout treatment. SN - 1471-4973 UR - https://www.unboundmedicine.com/medline/citation/35609384/Emerging_strategies_for_treating_gout_ DB - PRIME DP - Unbound Medicine ER -