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Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes.
BMC Pregnancy Childbirth. 2022 May 24; 22(1):432.BP

Abstract

BACKGROUND

Aerobic vaginitis (AV) is a vaginal inflammation characterized by disruption of the lactobacillus microbiota and increased counts of different aerobic bacteria. AV may result in severe complications, especially during pregnancy, including preterm delivery, neonatal and maternal infections. This study aimed to determine the prevalence of AV in the third trimester of pregnancy, and the relationship between AV and pregnancy outcomes.  METHODS: A cross-sectional descriptive study included 323 pregnant women attending for routine antenatal care in the Hue University Hospital. Vaginal samples collected at the third trimester of pregnancy were evaluated for AV according to the scoring system of Donders and cultured for identification of predominant bacteria. Pregnancy was followed to its end, and pregnancy outcomes were recorded for both mothers and infants.

RESULTS

The proportion of pregnant women diagnosed with AV in the third trimester was found to be 15.5%, with the vast majority of the cases (84%) displaying the light AV and 16% the moderate AV. The vaginal cultures in the women with AV revealed most frequently Streptococcus agalactiae (6%), followed by Enterococcus spp (4%), Staphylococcus aureus (4%), and Acinetobacter baumannii (2%). In addition, AV during the last trimester of pregnancy was associated with an increased risk of puerperal sepsis (OR 8.65, 95% CI: 1.41-53.16, p = 0.020) and there was a slightly increased risk for neonatal infections, which was statistically insignificant.

CONCLUSIONS

The proportion of AV is relatively high in Vietnamese pregnant women. Since it is associated with an increased risk of puerperal sepsis, it needs to be diagnosed and treated before delivery.

Authors+Show Affiliations

Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Becamex International Hospital, Thuan An City, Binh Duong, Vietnam.Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Department of OBGYN, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam. Center for Reproductive Endocrinology and Infertility, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia.Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia.Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia.Department of Microbiology, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen Street, Hue, Vietnam.Institute of Clinical Medicine, Department of Obstetrics and Gynecology, University of Tartu, 51014, Tartu, Estonia. Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden. Competence Centre On Health Technologies AS, 50410, Tartu, Estonia.Department of Microbiology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411, Tartu, EE, Estonia. reet.mandar@ut.ee. Competence Centre On Health Technologies AS, 50410, Tartu, Estonia. reet.mandar@ut.ee.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35610632

Citation

Nguyen, Anh Thi Chau, et al. "Aerobic Vaginitis in the Third Trimester and Its Impact On Pregnancy Outcomes." BMC Pregnancy and Childbirth, vol. 22, no. 1, 2022, p. 432.
Nguyen ATC, Le Nguyen NT, Hoang TTA, et al. Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes. BMC Pregnancy Childbirth. 2022;22(1):432.
Nguyen, A. T. C., Le Nguyen, N. T., Hoang, T. T. A., Nguyen, T. T., Tran, T. T. Q., Tran, D. N. T., Nguyen, A. T. K., Tran, L. M., Nguyen, D. H. C., Le, T. M., Ho, B. D., Rööp, T., Kõljalg, S., Štšepetova, J., Van Le, A., Salumets, A., & Mändar, R. (2022). Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes. BMC Pregnancy and Childbirth, 22(1), 432. https://doi.org/10.1186/s12884-022-04761-5
Nguyen ATC, et al. Aerobic Vaginitis in the Third Trimester and Its Impact On Pregnancy Outcomes. BMC Pregnancy Childbirth. 2022 May 24;22(1):432. PubMed PMID: 35610632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aerobic vaginitis in the third trimester and its impact on pregnancy outcomes. AU - Nguyen,Anh Thi Chau, AU - Le Nguyen,Na Thi, AU - Hoang,Thu Thi Anh, AU - Nguyen,Tuyen Thi, AU - Tran,Trang Thi Quynh, AU - Tran,Dan Nu Tam, AU - Nguyen,Anh Thi Kim, AU - Tran,Linh Manh, AU - Nguyen,Duc Huu Chau, AU - Le,Tam Minh, AU - Ho,Binh Duy, AU - Rööp,Tiiu, AU - Kõljalg,Siiri, AU - Štšepetova,Jelena, AU - Van Le,An, AU - Salumets,Andres, AU - Mändar,Reet, Y1 - 2022/05/24/ PY - 2021/12/27/received PY - 2022/5/13/accepted PY - 2022/5/24/entrez PY - 2022/5/25/pubmed PY - 2022/5/27/medline KW - Aerobic vaginitis KW - Neonatal infections KW - Pregnancy KW - Puerperal sepsis SP - 432 EP - 432 JF - BMC pregnancy and childbirth JO - BMC Pregnancy Childbirth VL - 22 IS - 1 N2 - BACKGROUND: Aerobic vaginitis (AV) is a vaginal inflammation characterized by disruption of the lactobacillus microbiota and increased counts of different aerobic bacteria. AV may result in severe complications, especially during pregnancy, including preterm delivery, neonatal and maternal infections. This study aimed to determine the prevalence of AV in the third trimester of pregnancy, and the relationship between AV and pregnancy outcomes.  METHODS: A cross-sectional descriptive study included 323 pregnant women attending for routine antenatal care in the Hue University Hospital. Vaginal samples collected at the third trimester of pregnancy were evaluated for AV according to the scoring system of Donders and cultured for identification of predominant bacteria. Pregnancy was followed to its end, and pregnancy outcomes were recorded for both mothers and infants. RESULTS: The proportion of pregnant women diagnosed with AV in the third trimester was found to be 15.5%, with the vast majority of the cases (84%) displaying the light AV and 16% the moderate AV. The vaginal cultures in the women with AV revealed most frequently Streptococcus agalactiae (6%), followed by Enterococcus spp (4%), Staphylococcus aureus (4%), and Acinetobacter baumannii (2%). In addition, AV during the last trimester of pregnancy was associated with an increased risk of puerperal sepsis (OR 8.65, 95% CI: 1.41-53.16, p = 0.020) and there was a slightly increased risk for neonatal infections, which was statistically insignificant. CONCLUSIONS: The proportion of AV is relatively high in Vietnamese pregnant women. Since it is associated with an increased risk of puerperal sepsis, it needs to be diagnosed and treated before delivery. SN - 1471-2393 UR - https://www.unboundmedicine.com/medline/citation/35610632/Aerobic_vaginitis_in_the_third_trimester_and_its_impact_on_pregnancy_outcomes. DB - PRIME DP - Unbound Medicine ER -