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Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions.

Abstract

The cochlear microphonics (CM), endocochlear potential (EP) and potassium ion activities in the endolymph and perilymph were measured in guinea pigs which received daily successive intramuscular injections of 500 mg/kg of body weight of kanamycin sulfate. Preyer's reflex threshold at 8 kHz began to increase after the 5th day of kanamycin treatment and disappeared on the 11th day. The maximum output of CM at 8 kHz began to decrease with a time course similar to Preyer's reflex. The potassium ion activities in the endolymph and perilymph and the EP did not change appreciably through all experimental days. The magnitude of the negative EP decreased in parallel with the reduction in CM and the relative potassium conductance (GK) between the endolymph and perilymph. These results lend support to the hypothesis that the site of production of the negative EP is probably in the hair cells and that the negative EP is mainly dependent on the permeability of the potassium ions in the organ of Corti.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3561972

Citation

Komune, S, et al. "Effects of Kanamycin Sulfate On Cochlear Potentials and Potassium Ion Permeability Through the Cochlear Partitions." ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, vol. 49, no. 1, 1987, pp. 9-16.
Komune S, Ide M, Nakano T, et al. Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions. ORL J Otorhinolaryngol Relat Spec. 1987;49(1):9-16.
Komune, S., Ide, M., Nakano, T., & Morimitsu, T. (1987). Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions. ORL; Journal for Oto-rhino-laryngology and Its Related Specialties, 49(1), pp. 9-16.
Komune S, et al. Effects of Kanamycin Sulfate On Cochlear Potentials and Potassium Ion Permeability Through the Cochlear Partitions. ORL J Otorhinolaryngol Relat Spec. 1987;49(1):9-16. PubMed PMID: 3561972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of kanamycin sulfate on cochlear potentials and potassium ion permeability through the cochlear partitions. AU - Komune,S, AU - Ide,M, AU - Nakano,T, AU - Morimitsu,T, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 9 EP - 16 JF - ORL; journal for oto-rhino-laryngology and its related specialties JO - ORL J. Otorhinolaryngol. Relat. Spec. VL - 49 IS - 1 N2 - The cochlear microphonics (CM), endocochlear potential (EP) and potassium ion activities in the endolymph and perilymph were measured in guinea pigs which received daily successive intramuscular injections of 500 mg/kg of body weight of kanamycin sulfate. Preyer's reflex threshold at 8 kHz began to increase after the 5th day of kanamycin treatment and disappeared on the 11th day. The maximum output of CM at 8 kHz began to decrease with a time course similar to Preyer's reflex. The potassium ion activities in the endolymph and perilymph and the EP did not change appreciably through all experimental days. The magnitude of the negative EP decreased in parallel with the reduction in CM and the relative potassium conductance (GK) between the endolymph and perilymph. These results lend support to the hypothesis that the site of production of the negative EP is probably in the hair cells and that the negative EP is mainly dependent on the permeability of the potassium ions in the organ of Corti. SN - 0301-1569 UR - https://www.unboundmedicine.com/medline/citation/3561972/Effects_of_kanamycin_sulfate_on_cochlear_potentials_and_potassium_ion_permeability_through_the_cochlear_partitions_ L2 - https://www.karger.com?DOI=10.1159/000275900 DB - PRIME DP - Unbound Medicine ER -