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Soy isoflavones plus soy protein effects on serum concentration of leptin in adults: A systematic review and meta-analysis of randomized clinical trials.
Clin Nutr ESPEN. 2022 06; 49:154-162.CN

Abstract

BACKGROUND

Some studies conducted on soy isoflavones and soy protein reflected that leptin can be reduced by soy isoflavones or soy protein. The aim of present study is to assess the effect of soy isoflavones plus soy protein on serum concentration of leptin among adults.

METHODS

To find randomized clinical trails (RCTs) assessing the effect of soy isoflavones containing soy protein on serum concentration of leptin in participants with age ≥18 years old, databases including PubMed, Scopus, ISI Web of Science, Cochrane and ClinicalTrials.gov were searched up to March 2021. We calculated the effect size by the mean change from baseline of leptin concentrations and its standard deviation for intervention and comparison groups. DerSimonian and Laird random effects model was used to estimate the overall summary effect and the heterogeneity. Risk of bias was conducted by Cochrane Collaboration's tool. Study protocol was registered in PROSPERO (No. CRD42021228366).

RESULTS

Eight articles with 421 participants and six articles with 336 participants were known to be eligible for systematic review and meta-analysis, respectively. A pooled analysis revealed that the combination of soy isoflavones and soy protein had a borderline non-significant on serum concentration of leptin (weighted mean difference (WMD): -1.03 ng/ml, 95% confidence interval (CI): -2.11, 0.05 ng/ml). This combination reduced serum leptin levels in studies with baseline levels of leptin ≤22 ng/ml, in short-term trials (≤56 days), studies that used soy isoflavones with dose ≤96 mg/day and among subjects with health risk factors or diseases.

CONCLUSION

Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin. However, making firm conclusion needs more studies on participants with different health condition, and different soy isoflavones doses and intervention duration.

Authors+Show Affiliations

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: Haririm1@nums.ac.ir.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35623806

Citation

Gholami, Ali, et al. "Soy Isoflavones Plus Soy Protein Effects On Serum Concentration of Leptin in Adults: a Systematic Review and Meta-analysis of Randomized Clinical Trials." Clinical Nutrition ESPEN, vol. 49, 2022, pp. 154-162.
Gholami A, Baradaran HR, Hariri M. Soy isoflavones plus soy protein effects on serum concentration of leptin in adults: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr ESPEN. 2022;49:154-162.
Gholami, A., Baradaran, H. R., & Hariri, M. (2022). Soy isoflavones plus soy protein effects on serum concentration of leptin in adults: A systematic review and meta-analysis of randomized clinical trials. Clinical Nutrition ESPEN, 49, 154-162. https://doi.org/10.1016/j.clnesp.2022.03.015
Gholami A, Baradaran HR, Hariri M. Soy Isoflavones Plus Soy Protein Effects On Serum Concentration of Leptin in Adults: a Systematic Review and Meta-analysis of Randomized Clinical Trials. Clin Nutr ESPEN. 2022;49:154-162. PubMed PMID: 35623806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy isoflavones plus soy protein effects on serum concentration of leptin in adults: A systematic review and meta-analysis of randomized clinical trials. AU - Gholami,Ali, AU - Baradaran,Hamid Reza, AU - Hariri,Mitra, Y1 - 2022/03/30/ PY - 2021/09/23/received PY - 2021/12/21/revised PY - 2022/03/11/accepted PY - 2022/5/27/entrez PY - 2022/5/28/pubmed PY - 2022/6/1/medline KW - Isoflavones KW - Leptin KW - Meta-analysis KW - Soy KW - Systematic review SP - 154 EP - 162 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 49 N2 - BACKGROUND: Some studies conducted on soy isoflavones and soy protein reflected that leptin can be reduced by soy isoflavones or soy protein. The aim of present study is to assess the effect of soy isoflavones plus soy protein on serum concentration of leptin among adults. METHODS: To find randomized clinical trails (RCTs) assessing the effect of soy isoflavones containing soy protein on serum concentration of leptin in participants with age ≥18 years old, databases including PubMed, Scopus, ISI Web of Science, Cochrane and ClinicalTrials.gov were searched up to March 2021. We calculated the effect size by the mean change from baseline of leptin concentrations and its standard deviation for intervention and comparison groups. DerSimonian and Laird random effects model was used to estimate the overall summary effect and the heterogeneity. Risk of bias was conducted by Cochrane Collaboration's tool. Study protocol was registered in PROSPERO (No. CRD42021228366). RESULTS: Eight articles with 421 participants and six articles with 336 participants were known to be eligible for systematic review and meta-analysis, respectively. A pooled analysis revealed that the combination of soy isoflavones and soy protein had a borderline non-significant on serum concentration of leptin (weighted mean difference (WMD): -1.03 ng/ml, 95% confidence interval (CI): -2.11, 0.05 ng/ml). This combination reduced serum leptin levels in studies with baseline levels of leptin ≤22 ng/ml, in short-term trials (≤56 days), studies that used soy isoflavones with dose ≤96 mg/day and among subjects with health risk factors or diseases. CONCLUSION: Soy isoflavones plus soy protein had a non-significant decreasing effect on the serum concentration of leptin. However, making firm conclusion needs more studies on participants with different health condition, and different soy isoflavones doses and intervention duration. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/35623806/Soy_isoflavones_plus_soy_protein_effects_on_serum_concentration_of_leptin_in_adults:_A_systematic_review_and_meta_analysis_of_randomized_clinical_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-4577(22)00189-9 DB - PRIME DP - Unbound Medicine ER -