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Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review.
Biomolecules. 2022 05 12; 12(5)B

Abstract

Neurodegenerative disorders including Parkinson's disease (PD), Huntington's disease (HD) and the most frequent, Alzheimer's disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding of disease development and pathology, treatments that stop AD progression are not yet available. The recent approval of sodium oligomannate (GV-971) for AD treatment in China emphasized the potential value of natural products for the treatment of neurodegenerative disorders. Many current clinical studies include the administration of a natural compound as a single and combination treatment. The most prominent mechanisms of action are anti-inflammatory and anti-oxidative activities, thus preserving cellular survival. Here, we review current natural products that are either approved or are in testing for a treatment of neurodegeneration in AD. In addition to the most important compounds of plant origin, we also put special emphasis on compounds from algae, given their neuroprotective activity and their underlying mechanisms of neuroprotection.

Authors+Show Affiliations

Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Straβe 55, 06366 Koethen, Germany.Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Straβe 55, 06366 Koethen, Germany.Paul Flechsig Institute for Brain Research, University of Leipzig, Liebigstraβe 19, 04103 Leipzig, Germany.Faculty of Applied Biosciences and Process Technology, Anhalt University of Applied Sciences, Bernburger Straβe 55, 06366 Koethen, Germany. Fraunhofer Institute for Cell Therapy and Immunology, Weinbergweg 22, 06120 Halle, Germany.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35625622

Citation

Klose, Jana, et al. "Natural Products From Plants and Algae for Treatment of Alzheimer's Disease: a Review." Biomolecules, vol. 12, no. 5, 2022.
Klose J, Griehl C, Roβner S, et al. Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules. 2022;12(5).
Klose, J., Griehl, C., Roβner, S., & Schilling, S. (2022). Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. Biomolecules, 12(5). https://doi.org/10.3390/biom12050694
Klose J, et al. Natural Products From Plants and Algae for Treatment of Alzheimer's Disease: a Review. Biomolecules. 2022 05 12;12(5) PubMed PMID: 35625622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Natural Products from Plants and Algae for Treatment of Alzheimer's Disease: A Review. AU - Klose,Jana, AU - Griehl,Carola, AU - Roβner,Steffen, AU - Schilling,Stephan, Y1 - 2022/05/12/ PY - 2022/03/06/received PY - 2022/05/05/revised PY - 2022/05/06/accepted PY - 2022/5/28/entrez PY - 2022/5/29/pubmed PY - 2022/6/1/medline KW - Alzheimer’s disease KW - clinical studies KW - drug development KW - neurodegeneration JF - Biomolecules JO - Biomolecules VL - 12 IS - 5 N2 - Neurodegenerative disorders including Parkinson's disease (PD), Huntington's disease (HD) and the most frequent, Alzheimer's disease (AD), represent one of the most urgent medical needs worldwide. Despite a significantly developed understanding of disease development and pathology, treatments that stop AD progression are not yet available. The recent approval of sodium oligomannate (GV-971) for AD treatment in China emphasized the potential value of natural products for the treatment of neurodegenerative disorders. Many current clinical studies include the administration of a natural compound as a single and combination treatment. The most prominent mechanisms of action are anti-inflammatory and anti-oxidative activities, thus preserving cellular survival. Here, we review current natural products that are either approved or are in testing for a treatment of neurodegeneration in AD. In addition to the most important compounds of plant origin, we also put special emphasis on compounds from algae, given their neuroprotective activity and their underlying mechanisms of neuroprotection. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/35625622/Natural_Products_from_Plants_and_Algae_for_Treatment_of_Alzheimer's_Disease:_A_Review_ DB - PRIME DP - Unbound Medicine ER -