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Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models.
Viruses. 2022 04 29; 14(5)V

Abstract

Nipah henipavirus (NiV) and Hendra henipavirus (HeV) are zoonotic emerging paramyxoviruses causing severe disease outbreaks in humans and livestock, mostly in Australia, India, Malaysia, Singapore and Bangladesh. Both are bat-borne viruses and in humans, their mortality rates can reach 60% in the case of HeV and 92% for NiV, thus being two of the deadliest viruses known for humans. Several factors, including a large cellular tropism and a wide zoonotic potential, con-tribute to their high pathogenicity. This review provides an overview of HeV and NiV pathogenicity mechanisms and provides a summary of their interactions with the immune systems of their different host species, including their natural hosts bats, spillover-hosts pigs, horses, and humans, as well as in experimental animal models. A better understanding of the interactions between henipaviruses and their hosts could facilitate the development of new therapeutic strategies and vaccine measures against these re-emerging viruses.

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Authors+Show Affiliations

Lawrence P
Science and Humanities Confluence Research Centre (EA 1598), Catholic University of Lyon (UCLy), 69002 Lyon, France.
Escudero-Pérez B
WHO Collaborating Centre for Arbovirus and Haemorrhagic Fever Reference and Research, Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany. German Centre for Infection Research (DZIF), Partner Site Hamburg-Luebeck-Borstel, 38124 Braunschweig, Germany.

MeSH

AnimalsChiropteraHendra VirusHenipavirus InfectionsHorsesImmune EvasionModels, AnimalNipah VirusSwine

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35632678

Citation

Lawrence, Philip, and Beatriz Escudero-Pérez. "Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt From Natural Infection and Animal Models." Viruses, vol. 14, no. 5, 2022.
Lawrence P, Escudero-Pérez B. Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models. Viruses. 2022;14(5).
Lawrence, P., & Escudero-Pérez, B. (2022). Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models. Viruses, 14(5). https://doi.org/10.3390/v14050936
Lawrence P, Escudero-Pérez B. Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt From Natural Infection and Animal Models. Viruses. 2022 04 29;14(5) PubMed PMID: 35632678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models. AU - Lawrence,Philip, AU - Escudero-Pérez,Beatriz, Y1 - 2022/04/29/ PY - 2022/03/22/received PY - 2022/04/27/revised PY - 2022/04/27/accepted PY - 2022/5/28/entrez PY - 2022/5/29/pubmed PY - 2022/6/1/medline KW - Hendra virus KW - Nipah virus KW - animal models KW - bat-borne KW - emergence KW - henipavirus KW - immune evasion mechanisms KW - pathogenesis KW - zoonosis JF - Viruses JO - Viruses VL - 14 IS - 5 N2 - Nipah henipavirus (NiV) and Hendra henipavirus (HeV) are zoonotic emerging paramyxoviruses causing severe disease outbreaks in humans and livestock, mostly in Australia, India, Malaysia, Singapore and Bangladesh. Both are bat-borne viruses and in humans, their mortality rates can reach 60% in the case of HeV and 92% for NiV, thus being two of the deadliest viruses known for humans. Several factors, including a large cellular tropism and a wide zoonotic potential, con-tribute to their high pathogenicity. This review provides an overview of HeV and NiV pathogenicity mechanisms and provides a summary of their interactions with the immune systems of their different host species, including their natural hosts bats, spillover-hosts pigs, horses, and humans, as well as in experimental animal models. A better understanding of the interactions between henipaviruses and their hosts could facilitate the development of new therapeutic strategies and vaccine measures against these re-emerging viruses. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/35632678/Henipavirus_Immune_Evasion_and_Pathogenesis_Mechanisms:_Lessons_Learnt_from_Natural_Infection_and_Animal_Models_ DB - PRIME DP - Unbound Medicine ER -