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Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022.
MMWR Morb Mortal Wkly Rep. 2022 06 03; 71(22):734-742.MM

Abstract

Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices (ACIP) has continued to recommend preexposure vaccination for these persons since 1980 (1), when smallpox was eradicated (2). In 2015, ACIP made recommendations for the use of ACAM2000, the only orthopoxvirus vaccine available in the United States at that time (3). During 2020-2021, ACIP considered evidence for use of JYNNEOS, a replication-deficient Vaccinia virus vaccine, as an alternative to ACAM2000. In November 2021, ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses. With these recommendations for use of JYNNEOS, two vaccines (ACAM2000 and JYNNEOS) are now available and recommended for preexposure prophylaxis against orthopoxvirus infection among persons at risk for such exposures.

Links

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Authors

Rao AK
No affiliation info available
Petersen BW
No affiliation info available
Whitehill F
No affiliation info available
Razeq JH
No affiliation info available
Isaacs SN
No affiliation info available
Merchlinsky MJ
No affiliation info available
Campos-Outcalt D
No affiliation info available
Morgan RL
No affiliation info available
Damon I
No affiliation info available
Sánchez PJ
No affiliation info available
Bell BP
No affiliation info available

MeSH

Advisory CommitteesHumansImmunizationMonkeypoxOccupational ExposureOrthopoxvirusSmallpoxUnited StatesVaccinationVaccinesVaccinia virus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35653347

Citation

Rao, Agam K., et al. "Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee On Immunization Practices - United States, 2022." MMWR. Morbidity and Mortality Weekly Report, vol. 71, no. 22, 2022, pp. 734-742.
Rao AK, Petersen BW, Whitehill F, et al. Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. MMWR Morb Mortal Wkly Rep. 2022;71(22):734-742.
Rao, A. K., Petersen, B. W., Whitehill, F., Razeq, J. H., Isaacs, S. N., Merchlinsky, M. J., Campos-Outcalt, D., Morgan, R. L., Damon, I., Sánchez, P. J., & Bell, B. P. (2022). Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. MMWR. Morbidity and Mortality Weekly Report, 71(22), 734-742. https://doi.org/10.15585/mmwr.mm7122e1
Rao AK, et al. Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee On Immunization Practices - United States, 2022. MMWR Morb Mortal Wkly Rep. 2022 06 3;71(22):734-742. PubMed PMID: 35653347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices - United States, 2022. AU - Rao,Agam K, AU - Petersen,Brett W, AU - Whitehill,Florence, AU - Razeq,Jafar H, AU - Isaacs,Stuart N, AU - Merchlinsky,Michael J, AU - Campos-Outcalt,Doug, AU - Morgan,Rebecca L, AU - Damon,Inger, AU - Sánchez,Pablo J, AU - Bell,Beth P, Y1 - 2022/06/03/ PY - 2022/6/2/entrez PY - 2022/6/3/pubmed PY - 2022/6/7/medline SP - 734 EP - 742 JF - MMWR. Morbidity and mortality weekly report JO - MMWR Morb Mortal Wkly Rep VL - 71 IS - 22 N2 - Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices (ACIP) has continued to recommend preexposure vaccination for these persons since 1980 (1), when smallpox was eradicated (2). In 2015, ACIP made recommendations for the use of ACAM2000, the only orthopoxvirus vaccine available in the United States at that time (3). During 2020-2021, ACIP considered evidence for use of JYNNEOS, a replication-deficient Vaccinia virus vaccine, as an alternative to ACAM2000. In November 2021, ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses. With these recommendations for use of JYNNEOS, two vaccines (ACAM2000 and JYNNEOS) are now available and recommended for preexposure prophylaxis against orthopoxvirus infection among persons at risk for such exposures. SN - 1545-861X UR - https://www.unboundmedicine.com/medline/citation/35653347/Use_of_JYNNEOS__Smallpox_and_Monkeypox_Vaccine_Live_Nonreplicating__for_Preexposure_Vaccination_of_Persons_at_Risk_for_Occupational_Exposure_to_Orthopoxviruses:_Recommendations_of_the_Advisory_Committee_on_Immunization_Practices___United_States_2022_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓101 ↑11]

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