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Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes.
Arzneimittelforschung. 1987 Jan; 37(1A):100-4.A

Abstract

Pharmacokinetic measurements of ferrous sulphate and ferric hydroxide-polymaltose complex on anaemic and non-anaemic rats have shown different postabsorption serum iron levels, invasion and elimination constants and distribution volumes for the two preparations. But nevertheless the absorption and utilization ratios of iron from both preparations are equal. It is therefore not justified to calculate utilization ratios for chemically different iron preparations on the basis of postabsorption serum iron measurements. Similar pharmacokinetic differences of these two iron preparations could also be found in clinical trials, which means that different serum iron increase results in an equal utilization ratio for both preparations. It is clear that ferrous sulphate and ferric hydroxide-polymaltose complex must have a different absorption mechanism. The postulated absorption mechanism is in agreement with all the facts known today and does explain the pharmacokinetic difference between the investigated preparations.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3566862

Citation

Geisser, P, and A Müller. "Pharmacokinetics of Iron Salts and Ferric Hydroxide-carbohydrate Complexes." Arzneimittel-Forschung, vol. 37, no. 1A, 1987, pp. 100-4.
Geisser P, Müller A. Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes. Arzneimittelforschung. 1987;37(1A):100-4.
Geisser, P., & Müller, A. (1987). Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes. Arzneimittel-Forschung, 37(1A), 100-4.
Geisser P, Müller A. Pharmacokinetics of Iron Salts and Ferric Hydroxide-carbohydrate Complexes. Arzneimittelforschung. 1987;37(1A):100-4. PubMed PMID: 3566862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes. AU - Geisser,P, AU - Müller,A, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 100 EP - 4 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 37 IS - 1A N2 - Pharmacokinetic measurements of ferrous sulphate and ferric hydroxide-polymaltose complex on anaemic and non-anaemic rats have shown different postabsorption serum iron levels, invasion and elimination constants and distribution volumes for the two preparations. But nevertheless the absorption and utilization ratios of iron from both preparations are equal. It is therefore not justified to calculate utilization ratios for chemically different iron preparations on the basis of postabsorption serum iron measurements. Similar pharmacokinetic differences of these two iron preparations could also be found in clinical trials, which means that different serum iron increase results in an equal utilization ratio for both preparations. It is clear that ferrous sulphate and ferric hydroxide-polymaltose complex must have a different absorption mechanism. The postulated absorption mechanism is in agreement with all the facts known today and does explain the pharmacokinetic difference between the investigated preparations. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3566862/Pharmacokinetics_of_iron_salts_and_ferric_hydroxide_carbohydrate_complexes_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:3566862 DB - PRIME DP - Unbound Medicine ER -