Tags

Type your tag names separated by a space and hit enter

Role of COVID-19 Vaccines in SARS-CoV-2 Variants.
Front Immunol. 2022; 13:898192.FI

Abstract

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a threat to the health of the global population. As the result of a global effort in the determination of origin, structure, and pathogenesis of SARS-CoV-2 and its variants, particularly such the variant of concern as Delta Variant and Omicron Variant, the understanding of SARS-CoV-2 are deepening and the development of vaccines against SARS-CoV-2 are ongoing. Currently, AstraZeneca-Vaxzevria/SII-Covishield vaccine, Janssen-Ad26.COV2.S vaccine, Moderna-mRNA-1273 vaccine, Pfizer BioNTech-Comirnaty vaccine and Sinovac-CoronaVac vaccine have been listed as WHO Emergency Use Listing (EUL) Qualified Vaccines by WHO. Because of the antigen escape caused by the mutation in variants, the effectiveness of vaccines, which are currently the main means of prevention and treatment, has been affected by varying degrees. Herein, we review the current status of mutations of SARS-CoV-2 variants, the different approaches used in the development of COVID-19 vaccines, and COVID-19 vaccine effectiveness against SARS-CoV-2 variants.

Links

PMC Free PDF

Authors+Show Affiliations

Zhou Z
Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China. Department of Clinical Pharmacology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Zhu Y
Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China. Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China.
Chu M
Department of Immunology, School of Basic Medical Sciences, Peking University, NHC Key Laboratory of Medical Immunology (Peking University), Beijing, China.

MeSH

2019-nCoV Vaccine mRNA-1273Ad26COVS1BNT162 VaccineCOVID-19COVID-19 VaccinesChAdOx1 nCoV-19HumansSARS-CoV-2Vaccines

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35669787

Citation

Zhou, Zhou, et al. "Role of COVID-19 Vaccines in SARS-CoV-2 Variants." Frontiers in Immunology, vol. 13, 2022, p. 898192.
Zhou Z, Zhu Y, Chu M. Role of COVID-19 Vaccines in SARS-CoV-2 Variants. Front Immunol. 2022;13:898192.
Zhou, Z., Zhu, Y., & Chu, M. (2022). Role of COVID-19 Vaccines in SARS-CoV-2 Variants. Frontiers in Immunology, 13, 898192. https://doi.org/10.3389/fimmu.2022.898192
Zhou Z, Zhu Y, Chu M. Role of COVID-19 Vaccines in SARS-CoV-2 Variants. Front Immunol. 2022;13:898192. PubMed PMID: 35669787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of COVID-19 Vaccines in SARS-CoV-2 Variants. AU - Zhou,Zhou, AU - Zhu,Yimiao, AU - Chu,Ming, Y1 - 2022/05/20/ PY - 2022/03/17/received PY - 2022/04/19/accepted PY - 2022/6/7/entrez PY - 2022/6/8/pubmed PY - 2022/6/9/medline KW - COVID-19 KW - COVID-19 vaccines KW - Delta variant KW - Omicron variant KW - SARS-CoV-2 SP - 898192 EP - 898192 JF - Frontiers in immunology JO - Front Immunol VL - 13 N2 - Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a threat to the health of the global population. As the result of a global effort in the determination of origin, structure, and pathogenesis of SARS-CoV-2 and its variants, particularly such the variant of concern as Delta Variant and Omicron Variant, the understanding of SARS-CoV-2 are deepening and the development of vaccines against SARS-CoV-2 are ongoing. Currently, AstraZeneca-Vaxzevria/SII-Covishield vaccine, Janssen-Ad26.COV2.S vaccine, Moderna-mRNA-1273 vaccine, Pfizer BioNTech-Comirnaty vaccine and Sinovac-CoronaVac vaccine have been listed as WHO Emergency Use Listing (EUL) Qualified Vaccines by WHO. Because of the antigen escape caused by the mutation in variants, the effectiveness of vaccines, which are currently the main means of prevention and treatment, has been affected by varying degrees. Herein, we review the current status of mutations of SARS-CoV-2 variants, the different approaches used in the development of COVID-19 vaccines, and COVID-19 vaccine effectiveness against SARS-CoV-2 variants. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/35669787/Role_of_COVID_19_Vaccines_in_SARS_CoV_2_Variants_ DB - PRIME DP - Unbound Medicine ER -