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Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review.
Int J Clin Pract. 2022; 2022:4774783.IJ

Abstract

BACKGROUND

Bacterial vaginosis (BV), caused by an imbalance in the vaginal microbiota, can be treated and prevented by probiotics. Pregnant women with BV can experience premature labor and spontaneous abortions. Probiotics and prebiotics promote the proliferation of beneficial microorganisms, alter the composition of the vaginal microbiota, and prevent intravaginal infections in postmenopausal women. In addition to reducing infection symptoms, pre/probiotics can also help prevent vaginal infections.

MATERIALS AND METHODS

A systematic review was conducted on studies from 2010 to 2020 to determine the efficacy of pre/probiotics on the treatment of BV in pregnant and nonpregnant women. The databases Medline, Scopus, Embase, and Google Scholar were systematically searched using the following keywords: "bacterial vaginosis," "probiotics," "prebiotics," and "synbiotics."

RESULTS

A total of 1,871 articles were found in the initial search, and 24 clinical trials were considered eligible. In studies comparing the effects of pre/probiotics and placebos with or without antibiotic therapy in patients with BV, significant differences in clinical outcomes were observed. Probiotics reduced the levels of IL-1β and IL-6, as well as the overall Nugent score and Amsel's criteria for restitution of a balanced vaginal microbiota. In addition, probiotics can reduce the vaginal colonization of Group B streptococci among pregnant women. In subjects treated with probiotics, BV cure rates were higher than those in subjects treated with antibiotics. There were no additional adverse events.

CONCLUSION

Pre/probiotic regimens, when used for BV treatment, are usually safe and can exhibit long-term and short-term benefits. In order to prove the benefits of pre/probiotics in BV treatment, additional high-quality research is required.

Authors+Show Affiliations

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Microbial Biotechnology Research Centre, Iran University of Medical Sciences, Tehran, Iran.Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.Behbahan Faculty of Medical Sciences, Behbahan, Iran.Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Microbial Biotechnology Research Centre, Iran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

35685517

Citation

Afifirad, Roghayeh, et al. "Effects of Pro/Prebiotics Alone Over Pro/Prebiotics Combined With Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: a Systematic Review." International Journal of Clinical Practice, vol. 2022, 2022, p. 4774783.
Afifirad R, Darb Emamie A, Golmoradi Zadeh R, et al. Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review. Int J Clin Pract. 2022;2022:4774783.
Afifirad, R., Darb Emamie, A., Golmoradi Zadeh, R., Asadollahi, P., Ghanavati, R., & Darbandi, A. (2022). Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review. International Journal of Clinical Practice, 2022, 4774783. https://doi.org/10.1155/2022/4774783
Afifirad R, et al. Effects of Pro/Prebiotics Alone Over Pro/Prebiotics Combined With Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: a Systematic Review. Int J Clin Pract. 2022;2022:4774783. PubMed PMID: 35685517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Pro/Prebiotics Alone over Pro/Prebiotics Combined with Conventional Antibiotic Therapy to Treat Bacterial Vaginosis: A Systematic Review. AU - Afifirad,Roghayeh, AU - Darb Emamie,Amir, AU - Golmoradi Zadeh,Rezvan, AU - Asadollahi,Parisa, AU - Ghanavati,Roya, AU - Darbandi,Atieh, Y1 - 2022/04/21/ PY - 2021/10/14/received PY - 2022/2/26/revised PY - 2022/3/8/accepted PY - 2022/6/10/entrez PY - 2022/6/11/pubmed PY - 2022/6/14/medline SP - 4774783 EP - 4774783 JF - International journal of clinical practice JO - Int J Clin Pract VL - 2022 N2 - BACKGROUND: Bacterial vaginosis (BV), caused by an imbalance in the vaginal microbiota, can be treated and prevented by probiotics. Pregnant women with BV can experience premature labor and spontaneous abortions. Probiotics and prebiotics promote the proliferation of beneficial microorganisms, alter the composition of the vaginal microbiota, and prevent intravaginal infections in postmenopausal women. In addition to reducing infection symptoms, pre/probiotics can also help prevent vaginal infections. MATERIALS AND METHODS: A systematic review was conducted on studies from 2010 to 2020 to determine the efficacy of pre/probiotics on the treatment of BV in pregnant and nonpregnant women. The databases Medline, Scopus, Embase, and Google Scholar were systematically searched using the following keywords: "bacterial vaginosis," "probiotics," "prebiotics," and "synbiotics." RESULTS: A total of 1,871 articles were found in the initial search, and 24 clinical trials were considered eligible. In studies comparing the effects of pre/probiotics and placebos with or without antibiotic therapy in patients with BV, significant differences in clinical outcomes were observed. Probiotics reduced the levels of IL-1β and IL-6, as well as the overall Nugent score and Amsel's criteria for restitution of a balanced vaginal microbiota. In addition, probiotics can reduce the vaginal colonization of Group B streptococci among pregnant women. In subjects treated with probiotics, BV cure rates were higher than those in subjects treated with antibiotics. There were no additional adverse events. CONCLUSION: Pre/probiotic regimens, when used for BV treatment, are usually safe and can exhibit long-term and short-term benefits. In order to prove the benefits of pre/probiotics in BV treatment, additional high-quality research is required. SN - 1742-1241 UR - https://www.unboundmedicine.com/medline/citation/35685517/Effects_of_Pro/Prebiotics_Alone_over_Pro/Prebiotics_Combined_with_Conventional_Antibiotic_Therapy_to_Treat_Bacterial_Vaginosis:_A_Systematic_Review. DB - PRIME DP - Unbound Medicine ER -