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Suppression of kindled seizures by cysteamine: dependence on injection-to-kindled seizure interval.
Eur J Pharmacol. 1987 Feb 10; 134(2):225-8.EJ

Abstract

A single injection of cysteamine, 200 mg/kg i.p., administered 4 h before a kindling session induces long-term suppression of kindled seizures. Injection of cysteamine 2, 4 or 6 h after or 24 h before the kindling session is either less effective or ineffective. The present series of experiments shows that the injection-to-kindled seizure interval is critically important for the long-term inhibition. We propose that the anticonvulsant effect is caused by an interaction of the cysteamine and the kindled seizure.

Authors

Cottrell GA
No affiliation info available
Robertson HA
No affiliation info available

MeSH

AmygdalaAnimalsAnticonvulsantsCysteamineHippocampusKindling, NeurologicMaleRatsRats, Inbred StrainsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3569411

Citation

Cottrell, G A., and H A. Robertson. "Suppression of Kindled Seizures By Cysteamine: Dependence On Injection-to-kindled Seizure Interval." European Journal of Pharmacology, vol. 134, no. 2, 1987, pp. 225-8.
Cottrell GA, Robertson HA. Suppression of kindled seizures by cysteamine: dependence on injection-to-kindled seizure interval. Eur J Pharmacol. 1987;134(2):225-8.
Cottrell, G. A., & Robertson, H. A. (1987). Suppression of kindled seizures by cysteamine: dependence on injection-to-kindled seizure interval. European Journal of Pharmacology, 134(2), 225-8.
Cottrell GA, Robertson HA. Suppression of Kindled Seizures By Cysteamine: Dependence On Injection-to-kindled Seizure Interval. Eur J Pharmacol. 1987 Feb 10;134(2):225-8. PubMed PMID: 3569411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Suppression of kindled seizures by cysteamine: dependence on injection-to-kindled seizure interval. AU - Cottrell,G A, AU - Robertson,H A, PY - 1987/2/10/pubmed PY - 1987/2/10/medline PY - 1987/2/10/entrez SP - 225 EP - 8 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 134 IS - 2 N2 - A single injection of cysteamine, 200 mg/kg i.p., administered 4 h before a kindling session induces long-term suppression of kindled seizures. Injection of cysteamine 2, 4 or 6 h after or 24 h before the kindling session is either less effective or ineffective. The present series of experiments shows that the injection-to-kindled seizure interval is critically important for the long-term inhibition. We propose that the anticonvulsant effect is caused by an interaction of the cysteamine and the kindled seizure. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/3569411/Suppression_of_kindled_seizures_by_cysteamine:_dependence_on_injection_to_kindled_seizure_interval_ DB - PRIME DP - Unbound Medicine ER -