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Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial.
Reprod Health. 2022 Jun 13; 19(1):137.RH

Abstract

BACKGROUND

Bacterial vaginosis (BV) is one of the most common vaginal infectious diseases in female reproductive period. Although the existing view is that probiotic treatment may be one of the feasible methods for the treatment of BV, different intervention methods lead to different treatment results. Therefore, up-to-date and comprehensive evidence in this regard is essential for the development of intervention strategies.

OBJECTIVE

This meta-analysis aims to systematically evaluate the role of probiotics in the treatment of BV in adult women.

METHODS

We searched the databases of Embase, Cochrane Library, PubMed, Web of Science and ClinicalTrials.gov for Randomized Controlled Trials published until November 7, 2021. Meta-analysis was performed by Revman5.3 software to systematically evaluate the clinical efficacy of probiotics adjunctive therapy in the treatment of BV. The literatures were screened and evaluated according to the inclusion and exclusion criteria. Chi-square test was used to test the heterogeneity between trials. Random or Fixed effect models were used to analyze the cure rate of BV.

RESULTS

Fourteen randomized controlled trials compared the efficacy of probiotics with antibiotic therapy (probiotics + antibiotics group) versus antibiotics alone or plus placebo (antibiotics (+ placebo) group) for BV [Risk Ratios (RR) = 1.23, 95% CI (1.05, 1.43), P = 0.009]. Three compared the efficacy of probiotics regimen (probiotics group) and antibiotics (antibiotics group) in the treatment of BV [RR = 1.12, 95% CI (0.60, 2.07), P = 0.72]. Another Three compared the efficacy of probiotics regimen (probiotics group) with placebo (placebo group) [RR = 15.20, 95% CI (3.87, 59.64), P < 0.0001].

CONCLUSION

Our meta-analysis suggests probiotics may play a positive role in the treatment of BV, but more strong evidence is needed.

Authors+Show Affiliations

Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.Department of Laboratory Medicine, ZhuJiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. muxuanchen@126.com. Microbiome Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. muxuanchen@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Review

Language

eng

PubMed ID

35698149

Citation

Chen, Rongdan, et al. "Probiotics Are a Good Choice for the Treatment of Bacterial Vaginosis: a Meta-analysis of Randomized Controlled Trial." Reproductive Health, vol. 19, no. 1, 2022, p. 137.
Chen R, Li R, Qing W, et al. Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial. Reprod Health. 2022;19(1):137.
Chen, R., Li, R., Qing, W., Zhang, Y., Zhou, Z., Hou, Y., Shi, Y., Zhou, H., & Chen, M. (2022). Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial. Reproductive Health, 19(1), 137. https://doi.org/10.1186/s12978-022-01449-z
Chen R, et al. Probiotics Are a Good Choice for the Treatment of Bacterial Vaginosis: a Meta-analysis of Randomized Controlled Trial. Reprod Health. 2022 Jun 13;19(1):137. PubMed PMID: 35698149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics are a good choice for the treatment of bacterial vaginosis: a meta-analysis of randomized controlled trial. AU - Chen,Rongdan, AU - Li,Rong, AU - Qing,Wei, AU - Zhang,Yingxuan, AU - Zhou,Zuyi, AU - Hou,Yi, AU - Shi,Yiya, AU - Zhou,Hongwei, AU - Chen,Muxuan, Y1 - 2022/06/13/ PY - 2022/1/21/received PY - 2022/5/28/accepted PY - 2022/6/13/entrez PY - 2022/6/14/pubmed PY - 2022/6/16/medline KW - Bacterial vaginosis KW - Cure rate KW - Meta-analysis KW - Probiotics SP - 137 EP - 137 JF - Reproductive health JO - Reprod Health VL - 19 IS - 1 N2 - BACKGROUND: Bacterial vaginosis (BV) is one of the most common vaginal infectious diseases in female reproductive period. Although the existing view is that probiotic treatment may be one of the feasible methods for the treatment of BV, different intervention methods lead to different treatment results. Therefore, up-to-date and comprehensive evidence in this regard is essential for the development of intervention strategies. OBJECTIVE: This meta-analysis aims to systematically evaluate the role of probiotics in the treatment of BV in adult women. METHODS: We searched the databases of Embase, Cochrane Library, PubMed, Web of Science and ClinicalTrials.gov for Randomized Controlled Trials published until November 7, 2021. Meta-analysis was performed by Revman5.3 software to systematically evaluate the clinical efficacy of probiotics adjunctive therapy in the treatment of BV. The literatures were screened and evaluated according to the inclusion and exclusion criteria. Chi-square test was used to test the heterogeneity between trials. Random or Fixed effect models were used to analyze the cure rate of BV. RESULTS: Fourteen randomized controlled trials compared the efficacy of probiotics with antibiotic therapy (probiotics + antibiotics group) versus antibiotics alone or plus placebo (antibiotics (+ placebo) group) for BV [Risk Ratios (RR) = 1.23, 95% CI (1.05, 1.43), P = 0.009]. Three compared the efficacy of probiotics regimen (probiotics group) and antibiotics (antibiotics group) in the treatment of BV [RR = 1.12, 95% CI (0.60, 2.07), P = 0.72]. Another Three compared the efficacy of probiotics regimen (probiotics group) with placebo (placebo group) [RR = 15.20, 95% CI (3.87, 59.64), P < 0.0001]. CONCLUSION: Our meta-analysis suggests probiotics may play a positive role in the treatment of BV, but more strong evidence is needed. SN - 1742-4755 UR - https://www.unboundmedicine.com/medline/citation/35698149/Probiotics_are_a_good_choice_for_the_treatment_of_bacterial_vaginosis:_a_meta_analysis_of_randomized_controlled_trial_ DB - PRIME DP - Unbound Medicine ER -