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Influence of polycythemia on blood volume and thermoregulation during exercise-heat stress.
J Appl Physiol (1985). 1987 Mar; 62(3):912-8.JA

Abstract

We studied the effects of autologous erythrocyte infusion on blood volume and thermoregulation during exercise in the heat. By use of a double-blind design, nine unacclimated male subjects were infused with either 600 ml of a NaCl-glucose-phosphate solution containing a approximately 50% hematocrit (n = 6, reinfusion) or 600 ml of this solution only (n = 3, saline). A heat stress test (HST) was attempted approximately 2-wk pre- and 48-h postinfusion during the late spring months. After 30 min of rest in a 20 degrees C antechamber, the HST consisted of a 120-min exposure (2 repeats of 15 min rest and 45 min treadmill walking) in a hot (35 degrees C, 45% rh) environment while euhydrated. Erythrocyte volume (RCV, 51Cr) and plasma volume (PV, 125I) were measured 24 h before each HST, and maximal O2 uptake (VO2max) was measured 24 h after each HST. Generally, no significant effects were found for the saline group. For the reinfusion group, RCV (11%, P less than 0.01) and VO2max (11%, P less than 0.05) increased after infusion, and the following observations were made: 1) the increased RCV was associated with a reduction in PV to maintain the same blood volume as during the preinfusion measurements; 2) polycythemia reduced total circulating protein but did not alter F-cell ratio, plasma osmolality, plasma protein content, or plasma lactate at rest or during exercise-heat stress; 3) polycythemia did not change the volume of fluid entering the intravascular space from rest to exercise-heat stress; and 4) polycythemia tended to reduce the rate of heat storage during exercise-heat stress.

Authors

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Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

3571088

Citation

Sawka, M N., et al. "Influence of Polycythemia On Blood Volume and Thermoregulation During Exercise-heat Stress." Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 62, no. 3, 1987, pp. 912-8.
Sawka MN, Dennis RC, Gonzalez RR, et al. Influence of polycythemia on blood volume and thermoregulation during exercise-heat stress. J Appl Physiol (1985). 1987;62(3):912-8.
Sawka, M. N., Dennis, R. C., Gonzalez, R. R., Young, A. J., Muza, S. R., Martin, J. W., Wenger, C. B., Francesconi, R. P., Pandolf, K. B., & Valeri, C. R. (1987). Influence of polycythemia on blood volume and thermoregulation during exercise-heat stress. Journal of Applied Physiology (Bethesda, Md. : 1985), 62(3), 912-8.
Sawka MN, et al. Influence of Polycythemia On Blood Volume and Thermoregulation During Exercise-heat Stress. J Appl Physiol (1985). 1987;62(3):912-8. PubMed PMID: 3571088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of polycythemia on blood volume and thermoregulation during exercise-heat stress. AU - Sawka,M N, AU - Dennis,R C, AU - Gonzalez,R R, AU - Young,A J, AU - Muza,S R, AU - Martin,J W, AU - Wenger,C B, AU - Francesconi,R P, AU - Pandolf,K B, AU - Valeri,C R, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 912 EP - 8 JF - Journal of applied physiology (Bethesda, Md. : 1985) JO - J Appl Physiol (1985) VL - 62 IS - 3 N2 - We studied the effects of autologous erythrocyte infusion on blood volume and thermoregulation during exercise in the heat. By use of a double-blind design, nine unacclimated male subjects were infused with either 600 ml of a NaCl-glucose-phosphate solution containing a approximately 50% hematocrit (n = 6, reinfusion) or 600 ml of this solution only (n = 3, saline). A heat stress test (HST) was attempted approximately 2-wk pre- and 48-h postinfusion during the late spring months. After 30 min of rest in a 20 degrees C antechamber, the HST consisted of a 120-min exposure (2 repeats of 15 min rest and 45 min treadmill walking) in a hot (35 degrees C, 45% rh) environment while euhydrated. Erythrocyte volume (RCV, 51Cr) and plasma volume (PV, 125I) were measured 24 h before each HST, and maximal O2 uptake (VO2max) was measured 24 h after each HST. Generally, no significant effects were found for the saline group. For the reinfusion group, RCV (11%, P less than 0.01) and VO2max (11%, P less than 0.05) increased after infusion, and the following observations were made: 1) the increased RCV was associated with a reduction in PV to maintain the same blood volume as during the preinfusion measurements; 2) polycythemia reduced total circulating protein but did not alter F-cell ratio, plasma osmolality, plasma protein content, or plasma lactate at rest or during exercise-heat stress; 3) polycythemia did not change the volume of fluid entering the intravascular space from rest to exercise-heat stress; and 4) polycythemia tended to reduce the rate of heat storage during exercise-heat stress. SN - 8750-7587 UR - https://www.unboundmedicine.com/medline/citation/3571088/Influence_of_polycythemia_on_blood_volume_and_thermoregulation_during_exercise_heat_stress_ L2 - https://journals.physiology.org/doi/10.1152/jappl.1987.62.3.912?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -