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Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine.
BMJ Case Rep. 2022 Jun 20; 15(6)BC

Abstract

Immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by autoantibodies against platelet antigens resulting in platelet destruction and inhibition of platelet production. Occasionally, an inciting event such as a virus or vaccination can precipitate ITP. Several cases of ITP have been reported after the BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) SARS-CoV-2 (COVID-19) vaccines. All reported cases of post-vaccination ITP have resolved with medical therapy until this case.A man in his mid-20s developed bleeding from ITP 2 weeks after receiving the second dose of the Pfizer SARS-CoV-2 vaccine. All inpatient medical treatment attempts failed. On hospital day 40, a splenectomy was performed and he ultimately recovered and was discharged.Awareness of potential vaccination side effects is a fundamental element of refining and improving patient safety. This case illustrates that given the right circumstances, serious refractory ITP can develop in response to the second dose of the Pfizer SARS-CoV-2 vaccine.

Authors+Show Affiliations

Internal Medicine, Orlando Regional Healthcare, Orlando, Florida, USA.Internal Medicine, Orlando Regional Healthcare, Orlando, Florida, USA.Pathology, Orlando Regional Healthcare, Orlando, Florida, USA.Department of Obstetrics and Gynecology, Orlando Health Corp, Orlando, Florida, USA stevecarlan@gmail.com.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

35725277

Citation

Koilpillai, Sarina, et al. "Severe Case of Refractory Immune Thrombocytopenic Purpura Requiring Splenectomy After the COVID-19 Vaccine." BMJ Case Reports, vol. 15, no. 6, 2022.
Koilpillai S, Dominguez B, Khan A, et al. Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine. BMJ Case Rep. 2022;15(6).
Koilpillai, S., Dominguez, B., Khan, A., & Carlan, S. (2022). Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine. BMJ Case Reports, 15(6). https://doi.org/10.1136/bcr-2022-250153
Koilpillai S, et al. Severe Case of Refractory Immune Thrombocytopenic Purpura Requiring Splenectomy After the COVID-19 Vaccine. BMJ Case Rep. 2022 Jun 20;15(6) PubMed PMID: 35725277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe case of refractory immune thrombocytopenic purpura requiring splenectomy after the COVID-19 vaccine. AU - Koilpillai,Sarina, AU - Dominguez,Bianca, AU - Khan,Azeem, AU - Carlan,Steve, Y1 - 2022/06/20/ PY - 2022/6/20/entrez PY - 2022/6/21/pubmed PY - 2022/6/23/medline KW - COVID-19 KW - Haematology (drugs and medicines) JF - BMJ case reports JO - BMJ Case Rep VL - 15 IS - 6 N2 - Immune thrombocytopenic purpura (ITP) is an autoimmune disorder caused by autoantibodies against platelet antigens resulting in platelet destruction and inhibition of platelet production. Occasionally, an inciting event such as a virus or vaccination can precipitate ITP. Several cases of ITP have been reported after the BTN162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) SARS-CoV-2 (COVID-19) vaccines. All reported cases of post-vaccination ITP have resolved with medical therapy until this case.A man in his mid-20s developed bleeding from ITP 2 weeks after receiving the second dose of the Pfizer SARS-CoV-2 vaccine. All inpatient medical treatment attempts failed. On hospital day 40, a splenectomy was performed and he ultimately recovered and was discharged.Awareness of potential vaccination side effects is a fundamental element of refining and improving patient safety. This case illustrates that given the right circumstances, serious refractory ITP can develop in response to the second dose of the Pfizer SARS-CoV-2 vaccine. SN - 1757-790X UR - https://www.unboundmedicine.com/medline/citation/35725277/Severe_case_of_refractory_immune_thrombocytopenic_purpura_requiring_splenectomy_after_the_COVID_19_vaccine_ DB - PRIME DP - Unbound Medicine ER -