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The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review.
Med Sci (Basel). 2022 06 08; 10(2)MS

Abstract

The rate of venous thromboembolism in COVID-19 patients has been reported to be 30% (deep vein thrombosis 20% and pulmonary embolism 18%). This has been shown to be higher in COVID-19 patients admitted to the ICU. Prophylactic anticoagulation may be sufficient at ward level, but not in intensive care. A retrospective chart review was undertaken in a large university hospital. The review included 276 patients from COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia groups. The timeframe included patients admitted between 23 February 2014 and 12 May 2021. Clinical characteristics, outcomes, blood results, rates of venous thromboembolism, and anticoagulation status were recorded. The incidence of venous thromboembolism in COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia was 10.91%, 13.69%, 13.33%, and 6.81%, respectively (p = 0.481). The incidence of pulmonary embolism was 7.27%, 10.95%, 3.33%, and 5.68%, respectively (p = 0.350). The incidence of deep vein thrombosis was 5.45%, 5.48%, 10.00%, and 1.14%, respectively (p = 0.117). Although most patients were prophylactically anticoagulated, venous thromboembolism still occurred. Venous thromboembolism remains an important differential to consider in critically ill COVID-19 patients. The current literature does not advise therapeutic anticoagulation for thromboprophylaxis in the ICU.

Authors+Show Affiliations

Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland.Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, D08 NHY1 Dublin, Ireland. Medicine, Trinity College Dublin, University of Dublin, DN02 PN40 Dublin, Ireland. Pulmonary Intensive Care Unit, Respiratory Institute, Hospital Clinic of Barcelona, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), University of Barcelona, CIBERes, 08036 Barcelona, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35736350

Citation

Boyd, Sean, et al. "The Incidence of Venous Thromboembolism in Critically Ill Patients With SARS-CoV-2 Infection Compared With Critically Ill Influenza and Community-Acquired Pneumonia Patients: a Retrospective Chart Review." Medical Sciences (Basel, Switzerland), vol. 10, no. 2, 2022.
Boyd S, Sheng Loh K, Lynch J, et al. The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review. Med Sci (Basel). 2022;10(2).
Boyd, S., Sheng Loh, K., Lynch, J., Alrashed, D., Muzzammil, S., Marsh, H., Masoud, M., Bin Ihsan, S., & Martin-Loeches, I. (2022). The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review. Medical Sciences (Basel, Switzerland), 10(2). https://doi.org/10.3390/medsci10020030
Boyd S, et al. The Incidence of Venous Thromboembolism in Critically Ill Patients With SARS-CoV-2 Infection Compared With Critically Ill Influenza and Community-Acquired Pneumonia Patients: a Retrospective Chart Review. Med Sci (Basel). 2022 06 8;10(2) PubMed PMID: 35736350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Incidence of Venous Thromboembolism in Critically Ill Patients with SARS-CoV-2 Infection Compared with Critically Ill Influenza and Community-Acquired Pneumonia Patients: A Retrospective Chart Review. AU - Boyd,Sean, AU - Sheng Loh,Kai, AU - Lynch,Jessie, AU - Alrashed,Dhari, AU - Muzzammil,Saad, AU - Marsh,Hannah, AU - Masoud,Mustafa, AU - Bin Ihsan,Salman, AU - Martin-Loeches,Ignacio, Y1 - 2022/06/08/ PY - 2022/03/30/received PY - 2022/05/10/revised PY - 2022/06/06/accepted PY - 2022/6/23/entrez PY - 2022/6/24/pubmed PY - 2022/6/28/medline KW - COVID-19 KW - DVT (deep vein thrombosis) KW - ICU (intensive care unit) KW - PE (pulmonary embolism) KW - VTE (venous thromboembolism) KW - community-acquired pneumonia KW - influenza JF - Medical sciences (Basel, Switzerland) JO - Med Sci (Basel) VL - 10 IS - 2 N2 - The rate of venous thromboembolism in COVID-19 patients has been reported to be 30% (deep vein thrombosis 20% and pulmonary embolism 18%). This has been shown to be higher in COVID-19 patients admitted to the ICU. Prophylactic anticoagulation may be sufficient at ward level, but not in intensive care. A retrospective chart review was undertaken in a large university hospital. The review included 276 patients from COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia groups. The timeframe included patients admitted between 23 February 2014 and 12 May 2021. Clinical characteristics, outcomes, blood results, rates of venous thromboembolism, and anticoagulation status were recorded. The incidence of venous thromboembolism in COVID-19 Wave 1, COVID-19 Wave 2, influenza, and community-acquired pneumonia was 10.91%, 13.69%, 13.33%, and 6.81%, respectively (p = 0.481). The incidence of pulmonary embolism was 7.27%, 10.95%, 3.33%, and 5.68%, respectively (p = 0.350). The incidence of deep vein thrombosis was 5.45%, 5.48%, 10.00%, and 1.14%, respectively (p = 0.117). Although most patients were prophylactically anticoagulated, venous thromboembolism still occurred. Venous thromboembolism remains an important differential to consider in critically ill COVID-19 patients. The current literature does not advise therapeutic anticoagulation for thromboprophylaxis in the ICU. SN - 2076-3271 UR - https://www.unboundmedicine.com/medline/citation/35736350/The_Incidence_of_Venous_Thromboembolism_in_Critically_Ill_Patients_with_SARS_CoV_2_Infection_Compared_with_Critically_Ill_Influenza_and_Community_Acquired_Pneumonia_Patients:_A_Retrospective_Chart_Review_ DB - PRIME DP - Unbound Medicine ER -