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Moderate alcohol consumption and the risk of breast cancer.

Abstract

In 1980, 89,538 U.S. women 34 to 59 years of age, with no history of cancer, completed an independently validated dietary questionnaire that included the use of beer, wine, and liquor. During the ensuring four years, 601 cases of breast cancer were diagnosed among cohort members. Among the women consuming 5 to 14 g of alcohol daily (about three to nine drinks per week), the age-adjusted relative risk of breast cancer was 1.3 (95 percent confidence limits, 1.1 and 1.7). Consumption of 15 g of alcohol or more per day was associated with a relative risk of 1.6 (95 percent confidence limits, 1.3 and 2.0; Mantel extension chi for linear trend = +4.2; P less than 0.0001). Adjustment for known breast cancer risk factors and a variety of nutritional variables did not materially alter this relation. Significant associations were observed for beer and liquor when considered separately. Among women without risk factors for breast cancer who were under 55 years of age, the relative risk associated with consumption of 15 g of alcohol or more per day was 2.5 (95 percent confidence limits, 1.5 and 4.2). These prospective data derived from measurements of alcohol intake recorded before the diagnosis of breast cancer confirm the findings of several previous case-control studies. Viewed collectively, they suggest that alcohol intake may contribute to the risk of breast cancer.

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  • Authors

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    Source

    The New England journal of medicine 316:19 1987 May 07 pg 1174-80

    MeSH

    Adult
    Alcohol Drinking
    Alcoholic Beverages
    Breast Neoplasms
    Diet Surveys
    Epidemiologic Methods
    Female
    Humans
    Middle Aged
    Risk
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    3574368

    Citation

    Willett, W C., et al. "Moderate Alcohol Consumption and the Risk of Breast Cancer." The New England Journal of Medicine, vol. 316, no. 19, 1987, pp. 1174-80.
    Willett WC, Stampfer MJ, Colditz GA, et al. Moderate alcohol consumption and the risk of breast cancer. N Engl J Med. 1987;316(19):1174-80.
    Willett, W. C., Stampfer, M. J., Colditz, G. A., Rosner, B. A., Hennekens, C. H., & Speizer, F. E. (1987). Moderate alcohol consumption and the risk of breast cancer. The New England Journal of Medicine, 316(19), pp. 1174-80.
    Willett WC, et al. Moderate Alcohol Consumption and the Risk of Breast Cancer. N Engl J Med. 1987 May 7;316(19):1174-80. PubMed PMID: 3574368.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Moderate alcohol consumption and the risk of breast cancer. AU - Willett,W C, AU - Stampfer,M J, AU - Colditz,G A, AU - Rosner,B A, AU - Hennekens,C H, AU - Speizer,F E, PY - 1987/5/7/pubmed PY - 1987/5/7/medline PY - 1987/5/7/entrez SP - 1174 EP - 80 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 316 IS - 19 N2 - In 1980, 89,538 U.S. women 34 to 59 years of age, with no history of cancer, completed an independently validated dietary questionnaire that included the use of beer, wine, and liquor. During the ensuring four years, 601 cases of breast cancer were diagnosed among cohort members. Among the women consuming 5 to 14 g of alcohol daily (about three to nine drinks per week), the age-adjusted relative risk of breast cancer was 1.3 (95 percent confidence limits, 1.1 and 1.7). Consumption of 15 g of alcohol or more per day was associated with a relative risk of 1.6 (95 percent confidence limits, 1.3 and 2.0; Mantel extension chi for linear trend = +4.2; P less than 0.0001). Adjustment for known breast cancer risk factors and a variety of nutritional variables did not materially alter this relation. Significant associations were observed for beer and liquor when considered separately. Among women without risk factors for breast cancer who were under 55 years of age, the relative risk associated with consumption of 15 g of alcohol or more per day was 2.5 (95 percent confidence limits, 1.5 and 4.2). These prospective data derived from measurements of alcohol intake recorded before the diagnosis of breast cancer confirm the findings of several previous case-control studies. Viewed collectively, they suggest that alcohol intake may contribute to the risk of breast cancer. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/3574368/Moderate_alcohol_consumption_and_the_risk_of_breast_cancer_ L2 - http://www.nejm.org/doi/full/10.1056/NEJM198705073161902?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -