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Neuroprotective Effect of Caffeine in Alzheimer's Disease.
Molecules. 2022 Jun 10; 27(12)M

Abstract

Alzheimer's disease (AD) is the leading cause of dementia, predicted to be the most significant health burden of the 21st century, with an estimated 131.5 million dementia patients by the year 2050. This review aims to provide an overview of the effect of caffeine on AD and cognition by summarizing relevant research conducted on this topic. We searched the Web of Science core collection and PubMed for studies related to the effect of caffeine on AD and cognition using title search terms: caffeine; coffee; Alzheimer's; cognition. There is suggestive evidence from clinical studies that caffeine is neuroprotective against dementia and possibly AD (20 out of 30 studies support this), but further studies, such as the "ideal" study proposed in this review, are required to prove this link. Clinical studies also indicate that caffeine is a cognitive normalizer and not a cognitive enhancer. Furthermore, clinical studies suggest the neuroprotective effect of caffeine might be confounded by gender. There is robust evidence based on in vivo and in vitro studies that caffeine has neuroprotective properties in AD animal models (21 out of 22 studies support this), but further studies are needed to identify the mechanistic pathways mediating these effects.

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Authors+Show Affiliations

M Yelanchezian YM
Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland 1023, New Zealand.
Waldvogel HJ
Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland 1023, New Zealand.
Faull RLM
Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland 1023, New Zealand.
Kwakowsky A
Centre for Brain Research, Department of Anatomy and Medical Imaging, Faculty of Medical and Health Science, University of Auckland, Auckland 1023, New Zealand. Pharmacology and Therapeutics, School of Medicine, Galway Neuroscience Centre, National University of Ireland Galway, H91 W5P7 Galway, Ireland.

MeSH

Alzheimer DiseaseAnimalsCaffeineCoffeeCognition DisordersHumansNeuroprotective Agents

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35744865

Citation

M Yelanchezian, Y Mukish, et al. "Neuroprotective Effect of Caffeine in Alzheimer's Disease." Molecules (Basel, Switzerland), vol. 27, no. 12, 2022.
M Yelanchezian YM, Waldvogel HJ, Faull RLM, et al. Neuroprotective Effect of Caffeine in Alzheimer's Disease. Molecules. 2022;27(12).
M Yelanchezian, Y. M., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2022). Neuroprotective Effect of Caffeine in Alzheimer's Disease. Molecules (Basel, Switzerland), 27(12). https://doi.org/10.3390/molecules27123737
M Yelanchezian YM, et al. Neuroprotective Effect of Caffeine in Alzheimer's Disease. Molecules. 2022 Jun 10;27(12) PubMed PMID: 35744865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Effect of Caffeine in Alzheimer's Disease. AU - M Yelanchezian,Y Mukish, AU - Waldvogel,Henry J, AU - Faull,Richard L M, AU - Kwakowsky,Andrea, Y1 - 2022/06/10/ PY - 2022/4/20/received PY - 2022/6/5/revised PY - 2022/6/6/accepted PY - 2022/6/24/entrez PY - 2022/6/25/pubmed PY - 2022/6/28/medline KW - Alzheimer’s disease KW - caffeine KW - coffee KW - cognition KW - dementia JF - Molecules (Basel, Switzerland) JO - Molecules VL - 27 IS - 12 N2 - Alzheimer's disease (AD) is the leading cause of dementia, predicted to be the most significant health burden of the 21st century, with an estimated 131.5 million dementia patients by the year 2050. This review aims to provide an overview of the effect of caffeine on AD and cognition by summarizing relevant research conducted on this topic. We searched the Web of Science core collection and PubMed for studies related to the effect of caffeine on AD and cognition using title search terms: caffeine; coffee; Alzheimer's; cognition. There is suggestive evidence from clinical studies that caffeine is neuroprotective against dementia and possibly AD (20 out of 30 studies support this), but further studies, such as the "ideal" study proposed in this review, are required to prove this link. Clinical studies also indicate that caffeine is a cognitive normalizer and not a cognitive enhancer. Furthermore, clinical studies suggest the neuroprotective effect of caffeine might be confounded by gender. There is robust evidence based on in vivo and in vitro studies that caffeine has neuroprotective properties in AD animal models (21 out of 22 studies support this), but further studies are needed to identify the mechanistic pathways mediating these effects. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/35744865/Neuroprotective_Effect_of_Caffeine_in_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -