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1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology In Vitro and In Vivo.
Molecules. 2022 Jun 18; 27(12)M

Abstract

Advanced glycation end products (AGEs) are stable products produced by the reaction of macromolecules such as proteins, lipids or nucleic acids with glucose or other reducing monosaccharides, which can be identified by immunohistochemistry in the senile plaques and neurofibrillary tangles of Alzheimer's disease (AD) patients. Growing evidence suggests that AGEs are important risk factors for the development and progression of AD. 1,8-cineole (CIN) is a monoterpenoid compound which exists in many plant essential oils and has been proven to have neuroprotective activity, but its specific effect and molecular mechanisms are not clear. In this study, AGEs-induced neuronal injury and intracerebroventricular-AGE animals as the possible models for AD were employed to investigate the effects of CIN on AD pathology as well as the molecular mechanisms involved both in vivo and in vitro. Our study demonstrated that CIN could ameliorate tau phosphorylation by down-regulating the activity of GSK-3β and reducing Aβ production by inhibiting the activity of BACE-1 both in vivo and in vitro. It is suggested that CIN has certain therapeutic value in the treatment of AD.

Authors+Show Affiliations

Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China. Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China. Medical College, Inner Mongolia Minzu University, Tongliao 028000, China.First Clinical Medical College, Inner Mongolia Minzu University, Tongliao 028000, China.First Clinical Medical College, Inner Mongolia Minzu University, Tongliao 028000, China.Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China. Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China. Medical College, Inner Mongolia Minzu University, Tongliao 028000, China.College of Nursing, Inner Mongolia Minzu University, Tongliao 028000, China. Institute of Dementia, Inner Mongolia Minzu University, Tongliao 028000, China.Institute of Pharmaceutical Chemistry and Pharmacology, Inner Mongolia Minzu University, Tongliao 028000, China. Inner Mongolia Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Tongliao 028000, China. Medical College, Inner Mongolia Minzu University, Tongliao 028000, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35745036

Citation

An, Fengmao, et al. "1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology in Vitro and in Vivo." Molecules (Basel, Switzerland), vol. 27, no. 12, 2022.
An F, Bai Y, Xuan X, et al. 1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology In Vitro and In Vivo. Molecules. 2022;27(12).
An, F., Bai, Y., Xuan, X., Bian, M., Zhang, G., & Wei, C. (2022). 1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology In Vitro and In Vivo. Molecules (Basel, Switzerland), 27(12). https://doi.org/10.3390/molecules27123913
An F, et al. 1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology in Vitro and in Vivo. Molecules. 2022 Jun 18;27(12) PubMed PMID: 35745036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 1,8-Cineole Ameliorates Advanced Glycation End Products-Induced Alzheimer's Disease-like Pathology In Vitro and In Vivo. AU - An,Fengmao, AU - Bai,Yuhan, AU - Xuan,Xinran, AU - Bian,Ming, AU - Zhang,Guowei, AU - Wei,Chengxi, Y1 - 2022/06/18/ PY - 2022/05/29/received PY - 2022/06/12/revised PY - 2022/06/15/accepted PY - 2022/6/24/entrez PY - 2022/6/25/pubmed PY - 2022/6/28/medline KW - 1,8-cineole KW - Alzheimer’s disease KW - advanced glycation end products KW - tau hyperphosphorylation KW - β-amyloid JF - Molecules (Basel, Switzerland) JO - Molecules VL - 27 IS - 12 N2 - Advanced glycation end products (AGEs) are stable products produced by the reaction of macromolecules such as proteins, lipids or nucleic acids with glucose or other reducing monosaccharides, which can be identified by immunohistochemistry in the senile plaques and neurofibrillary tangles of Alzheimer's disease (AD) patients. Growing evidence suggests that AGEs are important risk factors for the development and progression of AD. 1,8-cineole (CIN) is a monoterpenoid compound which exists in many plant essential oils and has been proven to have neuroprotective activity, but its specific effect and molecular mechanisms are not clear. In this study, AGEs-induced neuronal injury and intracerebroventricular-AGE animals as the possible models for AD were employed to investigate the effects of CIN on AD pathology as well as the molecular mechanisms involved both in vivo and in vitro. Our study demonstrated that CIN could ameliorate tau phosphorylation by down-regulating the activity of GSK-3β and reducing Aβ production by inhibiting the activity of BACE-1 both in vivo and in vitro. It is suggested that CIN has certain therapeutic value in the treatment of AD. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/35745036/18_Cineole_Ameliorates_Advanced_Glycation_End_Products_Induced_Alzheimer's_Disease_like_Pathology_In_Vitro_and_In_Vivo_ DB - PRIME DP - Unbound Medicine ER -